This is a proposal for the continuation of a study originally funded in the first CPRU Program Project Grant. The Chemoprevention of Cervical Cancer with Folic Acid Study (CCCFAS) is presently in its second year of patient accrual. The purpose of this double-blind randomized-controlled trial is to determine the effectiveness of oral folic acid therapy in preventing the development of cervical cancer in high-risk patients (those women with biopsy-proven mild or moderate dysplasia or koliocytotic atypia). The major study endpoint is the regression of dysplasia which is ascertained by PAP smear and colposcopy. A continuation was made necessary because of a delay of over two years in beginning patient accrual, due to the inability of the NCI and its contractor to provide the folic acid and placebo tablets and the lengthy FDA approval process.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA034847-08
Application #
3812484
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Satia, Jessie A; Kristal, Alan R; Patterson, Ruth E et al. (2002) Psychosocial factors and dietary habits associated with vegetable consumption. Nutrition 18:247-54
Levy, L; Patterson, R E; Kristal, A R et al. (2000) How well do consumers understand percentage daily value on food labels? Am J Health Promot 14:157-60, ii
Peterson Jr, A V; Kealey, K A; Mann, S L et al. (2000) Hutchinson Smoking Prevention Project: long-term randomized trial in school-based tobacco use prevention--results on smoking. J Natl Cancer Inst 92:1979-91
Satia, J A; Patterson, R E; Taylor, V M et al. (2000) Use of qualitative methods to study diet, acculturation, and health in Chinese-American women. J Am Diet Assoc 100:934-40
Neuhouser, M L; Kristal, A R; Patterson, R E (1999) Use of food nutrition labels is associated with lower fat intake. J Am Diet Assoc 99:45-53
Patterson, R E; Levy, L; Tinker, L F et al. (1999) Evaluation of a simplified vitamin supplement inventory developed for the Women's Health Initiative. Public Health Nutr 2:273-6
Kristal, A R; Glanz, K; Curry, S J et al. (1999) How can stages of change be best used in dietary interventions? J Am Diet Assoc 99:679-84
Neuhouser, M L; Patterson, R E; Levy, L (1999) Motivations for using vitamin and mineral supplements. J Am Diet Assoc 99:851-4
Patterson, R E; Kristal, A R; Levy, L et al. (1998) Validity of methods used to assess vitamin and mineral supplement use. Am J Epidemiol 148:643-9
Patterson, R E; Kristal, A R; Shannon, J et al. (1997) Using a brief household food inventory as an environmental indicator of individual dietary practices. Am J Public Health 87:272-5

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