Performance Outcome Assessment in Laryngeal Cancer

List, Marcy A.

Abstract

This two phase, five year longitudinal study examines the functional outcome of subgroups of head and neck cancer patients using the Performance Status Scale for Head and Neck Cancer Patients. The first phase is designed to develop """"""""expected performance profiles"""""""" for laryngeal cancer patients. In the second phase this methodology will be applied to other selected patient groups of clinical interest. The measurement of functional outcome in head and neck cancer patients is an important consideration in the selection and evaluation of treatment options and rehabilitation strategies. These patients suffer very unique disabilities in the area of speaking and eating, impairments which may significantly compromise their quality of life. Determining the degree, duration and expected recovery from these specific dysfunctions is critical to comprehensive care of the head and neck patient. In their previous study, the investigators developed and tested a new Performance Status Scale for Head and Neck Cancer Patients which directly assess areas of eating and speaking. The proposed study will extend this work and will use the scale to: a) evaluate the performance outcome of laryngeal cancer patients as a function of treatment type and time since surgery; b) to develop """"""""expected performance profiles"""""""" for laryngeal cancer patients; c) determine the relationship between observable functional impairments and physiological measures and d) identify and begin to develop profiles for other groups of head and neck cancer patients. A total of 383 laryngeal cancer patients representing four treatment types will be assessed at four points in time, within 2 weeks of surgery, at week 6, at week 12 and at 6 months. The assessment will consist of administration of the Performance Scale as well as the collection of relevant medical and personal demographic data. For patients at Northwestern, Hines and Loyola, objective measures of swallowing (modified barium swallow) and speech (percent understandability) will also be available and will be compared to ratings on the Performance Status Scale.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Program Projects (P01)
• Project #: 5P01CA040007-08
• Application #: 3772784
• Support Year: 8
• Fiscal Year: 1993

Institution

• Name: Northwestern University at Chicago
• City: Evanston
• State: IL
• Country: United States
• Zip Code: 60201

Publications

Logemann, Jerilyn A (2014) Critical Factors in the Oral Control Needed for Chewing and Swallowing. J Texture Stud 45:173-179

Pauloski, Barbara Roa; Logemann, Jerilyn A; Rademaker, Alfred W et al. (2013) Effects of enhanced bolus flavors on oropharyngeal swallow in patients treated for head and neck cancer. Head Neck 35:1124-31

Pauloski, Barbara Roa; Rademaker, Alfred W; Lazarus, Cathy et al. (2009) Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalities. Dysphagia 24:196-203

Logemann, Jeri A; Pauloski, Barbara Roa; Rademaker, Alfred W et al. (2008) Swallowing disorders in the first year after radiation and chemoradiation. Head Neck 30:148-58

Pauloski, Barbara Roa; Rademaker, Alfred W; Logemann, Jerilyn A et al. (2006) Relationship between swallow motility disorders on videofluorography and oral intake in patients treated for head and neck cancer with radiotherapy with or without chemotherapy. Head Neck 28:1069-76

Daggett, Alicia; Logemann, Jeri; Rademaker, Alfred et al. (2006) Laryngeal penetration during deglutition in normal subjects of various ages. Dysphagia 21:270-4

Smith, Christina H; Logemann, Jeri A; Burghardt, Wesley R et al. (2006) Oral and oropharyngeal perceptions of fluid viscosity across the age span. Dysphagia 21:209-17

Logemann, Jeri A; Rademaker, Alfred W; Pauloski, Barbara Roa et al. (2006) Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck 28:64-73

Logemann, Jeri A; Williams, Rohan B; Rademaker, Alfred et al. (2005) The relationship between observations and measures of oral and pharyngeal residue from videofluorography and scintigraphy. Dysphagia 20:226-31

Waters, Teresa M; Logemann, Jeri A; Pauloski, Barbara Roa et al. (2004) Beyond efficacy and effectiveness: conducting economic analyses during clinical trials. Dysphagia 19:109-19