This program project brings together a group of investigators and cooperating clinicians who have a major interest in quantifying and developing new procedures and patterns of care to minimize the effect of cancer treatment on the functional status of head and neck cancer patients as soon after treatment as possible. The 5 projects included in this grant reflect the philosophy that rehabilitation begins with prevention and detection and extends to pretreatment intervention and to the selection of treatment techniques. All of the 5 projects are proposed for 5 years. Project 1 compares 3 methods of swallow assessment in the evaluation of deglutition in head and neck cancer patients: modified barium swallow, biomechanical analysis, and manofluorography. We are interested in whether quantified techniques provide any additional information over observation of swallow. Project 2 examines functional effects of tracheostomy on swallow in head and neck cancer patients who are about to be decannulated. Project 3 examines the biomechanical effects of head and neck surgical procedures on swallowing function and on the patient's reactions to various bolus types and swallow maneuvers. A biomechanical analysis of swallow should enable us to define the changes in muscle pull created by head and neck surgical procedures and develop more effective swallow interventions and surgical reconstructions. Project 4 quantifies the effects of reconstruction on speech and swallowing function in 15 groups of oral cancer patients. This project proposes to continue the work begun in the first 5 years of the current project. Project 5 continues our previous development of a Performance Status Scale for head and neck cancer patients by examining functional changes in laryngeal cancer patients and developing functional profiles for these patients. We also propose to compare performance scores with objective data in a group of head and neck patients. the long term objective of this Program Project is to establish and maintain a cooperative interdisciplinary, inter-institutional team of investigators who will continue to develop and implement cancer rehabilitation protocols with carefully quantified outcomes to address key issues in the functional status of head and neck cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA040007-09
Application #
2090051
Study Section
Special Emphasis Panel (SRC (G1))
Project Start
1985-09-01
Project End
1996-04-30
Budget Start
1994-05-01
Budget End
1995-04-30
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Logemann, Jerilyn A (2014) Critical Factors in the Oral Control Needed for Chewing and Swallowing. J Texture Stud 45:173-179
Pauloski, Barbara Roa; Logemann, Jerilyn A; Rademaker, Alfred W et al. (2013) Effects of enhanced bolus flavors on oropharyngeal swallow in patients treated for head and neck cancer. Head Neck 35:1124-31
Pauloski, Barbara Roa; Rademaker, Alfred W; Lazarus, Cathy et al. (2009) Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalities. Dysphagia 24:196-203
Logemann, Jeri A; Pauloski, Barbara Roa; Rademaker, Alfred W et al. (2008) Swallowing disorders in the first year after radiation and chemoradiation. Head Neck 30:148-58
Pauloski, Barbara Roa; Rademaker, Alfred W; Logemann, Jerilyn A et al. (2006) Relationship between swallow motility disorders on videofluorography and oral intake in patients treated for head and neck cancer with radiotherapy with or without chemotherapy. Head Neck 28:1069-76
Daggett, Alicia; Logemann, Jeri; Rademaker, Alfred et al. (2006) Laryngeal penetration during deglutition in normal subjects of various ages. Dysphagia 21:270-4
Smith, Christina H; Logemann, Jeri A; Burghardt, Wesley R et al. (2006) Oral and oropharyngeal perceptions of fluid viscosity across the age span. Dysphagia 21:209-17
Logemann, Jeri A; Rademaker, Alfred W; Pauloski, Barbara Roa et al. (2006) Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck 28:64-73
Logemann, Jeri A; Williams, Rohan B; Rademaker, Alfred et al. (2005) The relationship between observations and measures of oral and pharyngeal residue from videofluorography and scintigraphy. Dysphagia 20:226-31
Waters, Teresa M; Logemann, Jeri A; Pauloski, Barbara Roa et al. (2004) Beyond efficacy and effectiveness: conducting economic analyses during clinical trials. Dysphagia 19:109-19

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