Abstract

The scientific core provides scientific support services of a generic or multi-user nature to the members of the Program Project, and is divided into three components: cell culture, radioisotope handling, and protein expression/antibody production.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA040042-14
Application #
6102235
Study Section
Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Walters, Dustin M; Lindberg, James M; Adair, Sara J et al. (2013) Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib. Neoplasia 15:143-55
Guerrero, Michael S; Parsons, J Thomas; Bouton, Amy H (2012) Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton. Genes Cancer 3:371-81
Owen, Katherine A; Abshire, Michelle Y; Tilghman, Robert W et al. (2011) FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PLoS One 6:e23123
Ohama, Takashi; Brautigan, David L (2010) Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. J Biol Chem 285:8711-8
Hall, Emily H; Balsbaugh, Jeremy L; Rose, Kristie L et al. (2010) Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK. Mol Cell Proteomics 9:2853-63
Slack-Davis, Jill K; Hershey, E Daniel; Theodorescu, Dan et al. (2009) Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Cancer Ther 8:2470-7
Hall, Emily H; Daugherty, Abbi E; Choi, Colin K et al. (2009) Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. J Biol Chem 284:34713-22
Molhoek, Kerrington R; McSkimming, Chantel C; Olson, Walter C et al. (2009) Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2. Cancer Immunol Immunother 58:867-76
Tilghman, Robert W; Parsons, J Thomas (2008) Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol 18:45-52
Vomastek, Tomas; Iwanicki, Marcin P; Burack, W Richard et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol 28:6954-66

Showing the most recent 10 out of 222 publications