Abstract

) The Cellular Imaging Core (Core C) will provide instrumentation and data analysis capability to support the study of intracellular signaling in single cells. This Core will allow us to create and staff a facility that brings cutting edge technology to the analysis of cell structure and cell movement and migration. Understanding signaling in """"""""time and space"""""""" requires the development of technologies to visualize signal transduction events in single cells and furthermore to visualize signals within defined compartments of such cells. Thus the Cell Imaging Core is key to the success of each of the projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA040042-17
Application #
6588434
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-05-01
Project End
2003-04-30
Budget Start
Budget End
Support Year
17
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Walters, Dustin M; Lindberg, James M; Adair, Sara J et al. (2013) Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib. Neoplasia 15:143-55
Guerrero, Michael S; Parsons, J Thomas; Bouton, Amy H (2012) Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton. Genes Cancer 3:371-81
Owen, Katherine A; Abshire, Michelle Y; Tilghman, Robert W et al. (2011) FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PLoS One 6:e23123
Ohama, Takashi; Brautigan, David L (2010) Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. J Biol Chem 285:8711-8
Hall, Emily H; Balsbaugh, Jeremy L; Rose, Kristie L et al. (2010) Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK. Mol Cell Proteomics 9:2853-63
Slack-Davis, Jill K; Hershey, E Daniel; Theodorescu, Dan et al. (2009) Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Cancer Ther 8:2470-7
Hall, Emily H; Daugherty, Abbi E; Choi, Colin K et al. (2009) Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. J Biol Chem 284:34713-22
Molhoek, Kerrington R; McSkimming, Chantel C; Olson, Walter C et al. (2009) Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2. Cancer Immunol Immunother 58:867-76
Tilghman, Robert W; Parsons, J Thomas (2008) Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol 18:45-52
Vomastek, Tomas; Iwanicki, Marcin P; Burack, W Richard et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol 28:6954-66

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