Abstract

As indicated in the separate parts of this application, we will be surveying cell samples from various patients and controls for chromosome constitution, oncogene expression and other specific gene alterations. Both normal and malignant cells will be required. In order to provide a systematic way to access materials from patients, we will continue to operate a tissue culture core to coordinate the isolation and distribution of samples. In addition, the core will be responsible for the establishment of EBV-transformed lymphoblastoid cell lines and tumor cell lines, which are required by two of the projects. Since its establishment four years ago, the Tissue Culture Core has processed over 1,500 peripheral blood and bone marrow samples and have established over 500 lymphoblastoid cell lines. We propose to continue this service and expand to accommodate the changing needs of the various investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA040046-07
Application #
3772805
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Clay-Gilmour, Alyssa I; Hahn, Theresa; Preus, Leah M et al. (2017) Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. Blood Adv 1:1717-1728
Churpek, Jane E; Marquez, Rafael; Neistadt, Barbara et al. (2016) Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. Cancer 122:304-11
Sasaki, Mark M; Skol, Andrew D; Hungate, Eric A et al. (2016) Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease. Inflamm Bowel Dis 22:20-7
Stoddart, Angela; Qian, Zhijian; Fernald, Anthony A et al. (2016) Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms. Haematologica 101:e232-6
Hungate, Eric A; Vora, Sapana R; Gamazon, Eric R et al. (2016) A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology. Nat Commun 7:10635
Shankar, Sunita; Pitchiaya, Sethuramasundaram; Malik, Rohit et al. (2016) KRAS Engages AGO2 to Enhance Cellular Transformation. Cell Rep 14:1448-1461
Vasanthakumar, Aparna; Arnovitz, Stephen; Marquez, Rafael et al. (2016) Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice. Blood 127:310-3
Wong, Jasmine C; Weinfurtner, Kelley M; Alzamora, Maria Del Pilar et al. (2015) Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Elife 4:
Sasaki, Mark M; Skol, Andrew D; Bao, Riyue et al. (2015) Integrated genomic analysis suggests MLL3 is a novel candidate susceptibility gene for familial nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 24:1222-8
Sundaravel, Sriram; Duggan, Ryan; Bhagat, Tushar et al. (2015) Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes. Proc Natl Acad Sci U S A 112:E6359-68

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