Abstract

Pet animals with spontaneous cancer are a valuable model in which to assess new treatments that may ultimately be of value for treatment of human cancer. These animals also provide a system wherein the biology and toxicity of administered treatments can be evaluated. The Animal Core serves as a regional referral center for dogs and cats with spontaneous tumors that will be treated on projects in this program. The Core provides the necessary diagnostic and staging services to assess whether animal patients are suitable for treatment in the program. It also provides the personnel resources for administration of treatments to dogs and with spontaneous tumors treated in this program. The Core also provides a framework for the follow-up of dogs with spontaneous tumors treated in this program. Accurate and follow-up assures very high quality in terms of completeness. Core personnel will also be in charge of sure that all necessary data are collected and archived in the computer at Duke University Medical Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA042745-14
Application #
6354030
Study Section
Project Start
2000-09-20
Project End
2001-06-30
Budget Start
Budget End
Support Year
14
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Stauffer, Paul R; van Rhoon, Gerard C (2016) Overview of bladder heating technology: matching capabilities with clinical requirements. Int J Hyperthermia 32:407-16
Juang, Titania; Stauffer, Paul R; Craciunescu, Oana A et al. (2014) Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. Int J Hyperthermia 30:176-83
Inman, Brant A; Stauffer, Paul R; Craciunescu, Oana A et al. (2014) A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer. Int J Hyperthermia 30:171-5
Angele, Martin K; Albertsmeier, Markus; Prix, Niclas J et al. (2014) Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study. Ann Surg 260:749-54; discussion 754-6
Zagar, Timothy M; Vujaskovic, Zeljko; Formenti, Silvia et al. (2014) Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer. Int J Hyperthermia 30:285-94
Viglianti, Benjamin L; Dewhirst, Mark W; Boruta, R J et al. (2014) Systemic anti-tumour effects of local thermally sensitive liposome therapy. Int J Hyperthermia 30:385-92
Oliveira, Tiago R; Stauffer, Paul R; Lee, Chen-Ting et al. (2013) Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study. Int J Hyperthermia 29:835-44
Dewhirst, Mark W; Landon, Chelsea D; Hofmann, Christina L et al. (2013) Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. Surg Oncol Clin N Am 22:545-61
Oliveira, Tiago R; Stauffer, Paul R; Lee, Chen-Ting et al. (2013) Preclinical Dosimetry of Magnetic Fluid Hyperthermia for Bladder Cancer. Proc SPIE Int Soc Opt Eng 8584:1656985
van Rhoon, Gerard C; Samaras, Theodoros; Yarmolenko, Pavel S et al. (2013) CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels? Eur Radiol 23:2215-27

Showing the most recent 10 out of 227 publications