The overall goal of the Engineering Core is to provide technical support for the four projects in this program This support is broad in scope since it includes assistance with routine clinical treatments as well as developing and determining the clinical feasibility of new technologies. This core seeks to provide an interface between the physics/engineering disciplines and clinical practice, It is believed that an active interaction between those developing technology and those trying to apply the technology is required to make progress in hyperthermia. Additionally, laboratory advances in the basic understanding of hyperthermic biology often use techniques that are impractical for testing or exploiting this knowledge in the clinical setting. Thus, physical/engineering support is required to solve problems of physical scale and material properties device deign and clinical implementation. When this support this support is integrated into the process at an early stage the transition from lab to clinical is much more efficient. This type of involvement with the various projects in the program is the goal of this core. This effort is defined upon three specific aims: 1. Provide technical support and quality assurance. 2. Developing equipment for inducing and monitoring hyperthermia. 3. Assist in the clinical implementation and quantitative evaluations of numerical models.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA042745-14
Application #
6354032
Study Section
Project Start
2000-09-20
Project End
2001-06-30
Budget Start
Budget End
Support Year
14
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Stauffer, Paul R; van Rhoon, Gerard C (2016) Overview of bladder heating technology: matching capabilities with clinical requirements. Int J Hyperthermia 32:407-16
Juang, Titania; Stauffer, Paul R; Craciunescu, Oana A et al. (2014) Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. Int J Hyperthermia 30:176-83
Inman, Brant A; Stauffer, Paul R; Craciunescu, Oana A et al. (2014) A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer. Int J Hyperthermia 30:171-5
Angele, Martin K; Albertsmeier, Markus; Prix, Niclas J et al. (2014) Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study. Ann Surg 260:749-54; discussion 754-6
Zagar, Timothy M; Vujaskovic, Zeljko; Formenti, Silvia et al. (2014) Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer. Int J Hyperthermia 30:285-94
Viglianti, Benjamin L; Dewhirst, Mark W; Boruta, R J et al. (2014) Systemic anti-tumour effects of local thermally sensitive liposome therapy. Int J Hyperthermia 30:385-92
van Rhoon, Gerard C; Samaras, Theodoros; Yarmolenko, Pavel S et al. (2013) CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels? Eur Radiol 23:2215-27
Kok, H Petra; Gellermann, Johanna; van den Berg, Cornelis A T et al. (2013) Thermal modelling using discrete vasculature for thermal therapy: A review. Int J Hyperthermia 29:336-45
Davis, Ryan M; Viglianti, Benjamin L; Yarmolenko, Pavel et al. (2013) A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. Int J Hyperthermia 29:569-81
Landon, Chelsea D; Benjamin, Sarah E; Ashcraft, Kathleen A et al. (2013) A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment. Int J Hyperthermia 29:528-38

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