Abstract

This Core facility provides analytical and synthetic expertise, and is specifically organized for three purposes: (a) the elucidation of chemical structures of chemoprotective enzyme inducers isolated from edible plants (Project No. 1); (b) the multigram synthesis of enzyme inducers isolated from plants (projects No.1), or identified by structure-activity studies, for evaluation as anticarcinogens in animal models (Project No. 1 and No. 3); and (c) the multigram synthesis of previously designed or identified Phase 2 enzyme inducers or their analogs for evaluation as anticarcinogens in animal systems (Project No. 1 and No. 3).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA044530-11
Application #
6269280
Study Section
Project Start
1998-01-01
Project End
1998-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Cho, Hye-Youn; Reddy, Sekhar P; Debiase, Andrea et al. (2005) Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med 38:325-43
Guyton, Kathryn Z; Kensler, Thomas W; Posner, Gary H (2003) Vitamin D and vitamin D analogs as cancer chemopreventive agents. Nutr Rev 61:227-38
Peleg, Sara; Posner, Gary H (2003) Vitamin D analogs as modulators of vitamin D receptor action. Curr Top Med Chem 3:1555-72
Ye, Lingxiang; Dinkova-Kostova, Albena T; Wade, Kristina L et al. (2002) Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin Chim Acta 316:43-53
Posner, Gary H; Woodard, Benjamin T; Crawford, Kenneth R et al. (2002) 2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology. Bioorg Med Chem 10:2353-65
Kensler, Thomas W; Egner, Patricia A; Wang, Jin-Bing et al. (2002) Strategies for chemoprevention of liver cancer. Eur J Cancer Prev 11 Suppl 2:S58-64
Dinkova-Kostova, A T (2002) Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcinogenic enzymes. Mini Rev Med Chem 2:595-610
Posner, Gary H; Halford, Bethany A; Peleg, Sara et al. (2002) Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing. J Med Chem 45:1723-30
Cho, Hye-Youn; Jedlicka, Anne E; Reddy, Sekhar P M et al. (2002) Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 26:175-82
Cho, Hye-Youn; Jedlicka, Anne E; Reddy, Sekhar P M et al. (2002) Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. Am J Respir Cell Mol Biol 26:42-51

Showing the most recent 10 out of 122 publications