Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA044704-08A1
Application #
5207398
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Lee, Y J; Galoforo, S S; Battle, P et al. (2001) Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy. Cancer Gene Ther 8:397-404
Lotz, M M; Rabinovitz, I; Mercurio, A M (2000) Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing. Am J Pathol 156:985-96
Bachelder, R E; Marchetti, A; Falcioni, R et al. (1999) Activation of p53 function in carcinoma cells by the alpha6beta4 integrin. J Biol Chem 274:20733-7
Jessup, J M; Ishii, S; Mitzoi, T et al. (1999) Carcinoembryonic antigen facilitates experimental metastasis through a mechanism that does not involve adhesion to liver cells. Clin Exp Metastasis 17:481-8
Jessup, J M; Battle, P; Waller, H et al. (1999) Reactive nitrogen and oxygen radicals formed during hepatic ischemia-reperfusion kill weakly metastatic colorectal cancer cells. Cancer Res 59:1825-9
Rabinovitz, I; Toker, A; Mercurio, A M (1999) Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol 146:1147-60
Walsh, S; Murphy, M; Silverman, M et al. (1999) p27 expression in inflammatory bowel disease-associated neoplasia. Further evidence of a unique molecular pathogenesis. Am J Pathol 155:1511-8
Pories, S E; Hess, D T; Swenson, K et al. (1998) Overexpression of pp60c-src elicits invasive behavior in rat colon epithelial cells. Gastroenterology 114:1287-95
Jessup, J M (1998) Tumor markers--prognostic and therapeutic implications for colorectal carcinoma. Surg Oncol 7:139-51
Jessup, J M; Loda, M (1998) Prognostic markers in rectal carcinoma. Semin Surg Oncol 15:131-40

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