Abstract

The goals of this Program Project are to identify the molecular lesions associated with aggressive clinical behavior of some breast cancers and to translate these molecular insights into prognostic indicators. We will continue our multidisciplinary approach toward understanding the fundamental differences among patients in the cellular biology of the malignant epithelium and its reactive stroma. Three projects will concentrate on the molecular lesions in the tumor cells, while two projects will concentrate on the stroma. Project 1 will evaluate dysregulation of four ETS related transcription factors and their relationship to HER2 oncogene overexpression. Project 2 will clone the target genes of three newly identified amplicons in breast cancer. The next project will evaluate breast cancer molecular cytogenetics using newly developed technologies. Translation to clinically relevant assays will be the responsibility of the Immunopathology Core which will apply discoveries of the Projects to slide-based assays using archival paraffin- embedded tissues. Additional support for the Projects will come from a Clinical Core for tissue accrual, a Biostatistics and Database Core, a Cell Biology Core, and an Administrative Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
7P01CA044768-14
Application #
2894712
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Program Officer
Lively, Tracy (LUGO)
Project Start
1987-06-01
Project End
2001-12-31
Budget Start
1999-04-01
Budget End
2001-12-31
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Hwang, E Shelley; DeVries, Sandy; Chew, Karen L et al. (2004) Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res 10:5160-7
Shelley Hwang, E; Nyante, Sarah J; Yi Chen, Yunn et al. (2004) Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma. Cancer 100:2562-72
Gupta, Anu; Yang, Li Xi; Chen, Ling chun (2002) Study of the G2/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene. Int J Radiat Oncol Biol Phys 52:822-30
Neve, Richard M; Ylstra, Bauke; Chang, Chuan-Hsiung et al. (2002) ErbB2 activation of ESX gene expression. Oncogene 21:3934-8
Thor, Ann D; Eng, Clarence; Devries, Sandy et al. (2002) Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization. Hum Pathol 33:628-31
Liu, S; Edgerton, S M; Moore 2nd, D H et al. (2001) Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer. Clin Cancer Res 7:1716-23
Waldman, F M; Hwang, E S; Etzell, J et al. (2001) Genomic alterations in tubular breast carcinomas. Hum Pathol 32:222-6
Neve, R M; Nielsen, U B; Kirpotin, D B et al. (2001) Biological effects of anti-ErbB2 single chain antibodies selected for internalizing function. Biochem Biophys Res Commun 280:274-9
Thor, A D; Edgerton, S M; Liu, S et al. (2001) Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers. Clin Cancer Res 7:2415-24
Eppenberger-Castori, S; Kueng, W; Benz, C et al. (2001) Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay. J Clin Oncol 19:645-56

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