Abstract

) The overall objective of this revised renewal application remains to discover and characterize novel cancer chemopreventive agents derived from the natural products. This Core replaces Project 4 of the renewal application. It will continue to utilize murine mammary gland organ culture (MMOC) assay to evaluate biological effectiveness of potential chemopreventive agents identified in the initial screens of Project 3. As indicated by the theme of this program, extracts or fractions provided by Project 2 and considered as active leads by Project 3 will be first evaluated for chemopreventive activity against 7,12- dimethylbenz(a)anthracene (DMBA)-induced mammary lesions in organ cultures. If the extract shows significant activity in one or both of these systems, bioassay-guided fractionation will be performed (Project 2 and 3). Newly identified agents, which are considered active in Project 3 are again evaluated against mammary lesion formation. In addition to evaluating extracts and pure compounds for their activity against DMBA-induced alveolar lesions, we will also evaluate potential plant extracts and pure compounds with possible anti-estogenic activity (Project 3) for their effect on estrogen-proesterone-dependent DMBA-induced mammary ductal-lesions. In summary, this MMOC Core will serve to provide a secondary discriminatory assay system to select new chemopreventive agents for further evaluation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA048112-11
Application #
6563828
Study Section
Subcommittee G - Education (NCI)
Project Start
2002-02-01
Project End
2003-01-31
Budget Start
Budget End
Support Year
11
Fiscal Year
2002
Total Cost
$228,401
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Type
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Youn, Ui Joung; Sripisut, Tawanun; Park, Eun-Jung et al. (2015) Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg Med Chem Lett 25:4719-23
Chai, Xingyun; Youn, Ui Joung; Sun, Dianqing et al. (2014) Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10. J Nat Prod 77:227-33
Ihsan-ul-Haq; Mirza, Bushra; Kondratyuk, Tamara P et al. (2013) Preliminary evaluation for cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants of Pakistan. Pharm Biol 51:316-28
Ihsan-ul-Haq; Youn, Ui Joung; Chai, Xingyun et al. (2013) Biologically active withanolides from Withania coagulans. J Nat Prod 76:22-8
St John, Sarah E; Jensen, Katherine C; Kang, Soosung et al. (2013) Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. Bioorg Med Chem 21:6022-37
Conda-Sheridan, Martin; Park, Eun-Jung; Beck, Daniel E et al. (2013) Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential. J Med Chem 56:2581-605
Park, Eun-Jung; Pezzuto, John M; Jang, Kyoung Hwa et al. (2012) Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Nat Prod Commun 7:789-94
Kondratyuk, Tamara P; Park, Eun-Jung; Yu, Rui et al. (2012) Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents. Mar Drugs 10:451-64
Reddy, P V Narasimha; Jensen, Katherine C; Mesecar, Andrew D et al. (2012) Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2. J Med Chem 55:367-77
Mayhoub, Abdelrahman S; Marler, Laura; Kondratyuk, Tamara P et al. (2012) Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. Bioorg Med Chem 20:510-20

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