Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA054425-06
Application #
6269485
Study Section
Project Start
1998-03-16
Project End
1999-01-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Center for Molecular Medicine/Immunology
Department
Type
DUNS #
City
Belleville
State
NJ
Country
United States
Zip Code
07950
Cardillo, Thomas M; Karacay, Habibe; Goldenberg, David M et al. (2004) Improved targeting of pancreatic cancer: experimental studies of a new bispecific antibody, pretargeting enhancement system for immunoscintigraphy. Clin Cancer Res 10:3552-61
Gold, David V; Modrak, David E; Schutsky, Keith et al. (2004) Combined 90Yttrium-DOTA-labeled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft. Int J Cancer 109:618-26
Gold, David V; Schutsky, Keith; Modrak, David et al. (2003) Low-dose radioimmunotherapy ((90)Y-PAM4) combined with gemcitabine for the treatment of experimental pancreatic cancer. Clin Cancer Res 9:3929S-37S
Reddy, P K; Gold, D V; Cardillo, T M et al. (2003) Interferon-gamma upregulates MUC1 expression in haematopoietic and epithelial cancer cell lines, an effect associated with MUC1 mRNA induction. Eur J Cancer 39:397-404
Cardillo, Thomas M; Blumenthal, Rosalyn; Ying, Zhiliang et al. (2002) Combined gemcitabine and radioimmunotherapy for the treatment of pancreatic cancer. Int J Cancer 97:386-92
Hajjar, George; Sharkey, Robert M; Burton, Jack et al. (2002) Phase I radioimmunotherapy trial with iodine-131--labeled humanized MN-14 anti-carcinoembryonic antigen monoclonal antibody in patients with metastatic gastrointestinal and colorectal cancer. Clin Colorectal Cancer 2:31-42
Modrak, David E; Rodriguez, Marisol D; Goldenberg, David M et al. (2002) Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts. Int J Oncol 20:379-84
O'Hara, J A; Blumenthal, R D; Grinberg, O Y et al. (2001) Response to radioimmunotherapy correlates with tumor pO2 measured by EPR oximetry in human tumor xenografts. Radiat Res 155:466-73
Gold, D V; Cardillo, T M (2001) Monoclonal antibody G47 engineered to be reactive with colorectal tumor mucin. Hybrid Hybridomics 20:343-50
Gold, D V; Cardillo, T; Goldenberg, D M et al. (2001) Localization of pancreatic cancer with radiolabeled monoclonal antibody PAM4. Crit Rev Oncol Hematol 39:147-54

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