Abstract

The coordination Core will subserve all three projects of the Program for several key functions. These include: monitoring of budgets, management of regulatory affairs, data management, coordination of clinical studies and biostatistical support. In addition, an External Scientific Advisory Committee functions through this core to provide review and recommendations to the senior leaders of the program. The core will e directed by Dr. Chang. All of the individuals in this core are highly experienced in their assigned tasks.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA059327-10
Application #
6579880
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
10
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Teitz-Tennenbaum, Seagal; Li, Qiao; Davis, Mary A et al. (2009) Radiotherapy combined with intratumoral dendritic cell vaccination enhances the therapeutic efficacy of adoptive T-cell transfer. J Immunother 32:602-12
Teitz-Tennenbaum, Seagal; Li, Qiao; Okuyama, Ryuji et al. (2008) Mechanisms involved in radiation enhancement of intratumoral dendritic cell therapy. J Immunother 31:345-58
Redman, Bruce G; Chang, Alfred E; Whitfield, Joel et al. (2008) Phase Ib trial assessing autologous, tumor-pulsed dendritic cells as a vaccine administered with or without IL-2 in patients with metastatic melanoma. J Immunother 31:591-8
Teitz-Tennenbaum, Seagal; Li, Qiao; Davis, Mary A et al. (2008) Dendritic cells pulsed with keyhole limpet hemocyanin and cryopreserved maintain anti-tumor activity in a murine melanoma model. Clin Immunol 129:482-91
Pinnix, Chelsea C; Herlyn, Meenhard (2007) The many faces of Notch signaling in skin-derived cells. Pigment Cell Res 20:458-65
Govindarajan, Baskaran; Sligh, James E; Vincent, Bethaney J et al. (2007) Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest 117:719-29
Topczewska, Jolanta M; Postovit, Lynne-Marie; Margaryan, Naira V et al. (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 12:925-32
Pilon-Thomas, Shari; Verhaegen, Monique; Kuhn, Lisa et al. (2006) Induction of anti-tumor immunity by vaccination with dendritic cells pulsed with anti-CD44 IgG opsonized tumor cells. Cancer Immunol Immunother 55:1238-46
Qin, Jian-Zhong; Xin, Hong; Sitailo, Leonid A et al. (2006) Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Res 66:9636-45
Pilon-Thomas, Shari; Li, Wenbin; Briggs, Jon J et al. (2006) Immunostimulatory effects of CpG-ODN upon dendritic cell-based immunotherapy in a murine melanoma model. J Immunother 29:381-7

Showing the most recent 10 out of 103 publications