Abstract

This Core is responsible for the collection, typing, and storage of sera from all patients with monoclonal gammopathies. . Clinical and laboratory information on these patients will be collected and abstracted and a clinical database will be created for rapid retrieval and analysis. Patients will be characterized as having monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM), smoldering multiple myeloma (SMM), primary systemic amyloidosis (AL), and related disorders. Bone marrow and peripheral cells will be collected in DMSO for current and future studies for all projects. The morphologic, proliferative, and apoptotic status of plasma cells of patients with MGUS, MM, SMM, and AL will be done. Cells from bone marrow and peripheral blood will be collected and sorted by flow cytometry. We will continue to develop cell lines from patients with multiple myeloma. We have successfully integrated Cell Bank data into the Monoclonal Gammopathies databank. This allows ready retrieval of specimens based on the patient's diagnosis and clinical features and the number of cells available for the investigators of this Program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA062242-07
Application #
6416225
Study Section
Project Start
2001-02-01
Project End
2002-01-31
Budget Start
Budget End
Support Year
7
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Lwin, S T; Fowler, J A; Drake, M T et al. (2017) A loss of host-derived MMP-7 promotes myeloma growth and osteolytic bone disease in vivo. Mol Cancer 16:49
Gonsalves, W I; Rajkumar, S V; Dispenzieri, A et al. (2017) Quantification of circulating clonal plasma cells via multiparametric flow cytometry identifies patients with smoldering multiple myeloma at high risk of progression. Leukemia 31:130-135
Mullikin, Trey C; Rajkumar, S Vincent; Dispenzieri, Angela et al. (2016) Clinical characteristics and outcomes in biclonal gammopathies. Am J Hematol 91:473-5
Gonsalves, Wilson I; Timm, Michael M; Rajkumar, S Vincent et al. (2016) The prognostic significance of CD45 expression by clonal bone marrow plasma cells in patients with newly diagnosed multiple myeloma. Leuk Res 44:32-9
Kaufman, Gregory P; Dispenzieri, Angela; Gertz, Morie A et al. (2015) Kinetics of organ response and survival following normalization of the serum free light chain ratio in AL amyloidosis. Am J Hematol 90:181-6
Gonsalves, W I; Leung, N; Rajkumar, S V et al. (2015) Improvement in renal function and its impact on survival in patients with newly diagnosed multiple myeloma. Blood Cancer J 5:e296
Landgren, O; Graubard, B I; Katzmann, J A et al. (2014) Racial disparities in the prevalence of monoclonal gammopathies: a population-based study of 12,482 persons from the National Health and Nutritional Examination Survey. Leukemia 28:1537-42
Kumar, S K; Dispenzieri, A; Lacy, M Q et al. (2014) Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients. Leukemia 28:1122-8
Gonsalves, Wilson I; Rajkumar, S Vincent; Go, Ronald S et al. (2014) Trends in survival of patients with primary plasma cell leukemia: a population-based analysis. Blood 124:907-12
Wong, Tina W; Doyle, Alfred D; Lee, James J et al. (2014) Eosinophils regulate peripheral B cell numbers in both mice and humans. J Immunol 192:3548-58

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