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Connelly, Stephen; DeMartino, Jessica K; Boger, Dale L et al. (2013) Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase. Biochemistry 52:5133-44
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DeMartino, Jessica K; Hwang, Inkyu; Connelly, Stephen et al. (2008) Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. J Med Chem 51:5441-8
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Xu, Lan; Chong, Youhoon; Hwang, Inkyu et al. (2007) Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem 282:13033-46
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DeMartino, Jessica K; Hwang, Inkyu; Xu, Lan et al. (2006) Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. J Med Chem 49:2998-3002
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Cheng, Heng; Hwang, Inkyu; Chong, Youhoon et al. (2005) Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. Bioorg Med Chem 13:3593-9
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Cheng, Heng; Chong, Youhoon; Hwang, Inkyu et al. (2005) Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. Bioorg Med Chem 13:3577-85
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