Abstract

Purpose: 1) To maintain suitable procedures for collection, distribution, and processing of clinical samples (i.e., bone marrow and peripheral blood) from patients with chronic myelogenous leukemia and normal subjects. 2) To prepare enriched normal and leukemic progenitor cell populations and maintain banks of frozen leukemic and normal progenitor cells for use of investigators. 3. Maintenance of permanent Ph+ and Ph-negative cell lines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA064593-03
Application #
5209359
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Berger, Alice H; Niki, Masaru; Morotti, Alessandro et al. (2010) Identification of DOK genes as lung tumor suppressors. Nat Genet 42:216-23
Rossi, Ferdinand; Yozgat, Yasemin; de Stanchina, Elisa et al. (2010) Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib. Mol Cancer Res 8:1271-83
Guo, Tianhua; Hajdu, Mihai; Agaram, Narasimhan P et al. (2009) Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: an in vitro mutagenesis screen for drug resistance. Clin Cancer Res 15:6862-70
Antczak, Christophe; Veach, Darren R; Ramirez, Christina N et al. (2009) Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett 19:6872-6
Kashiwada, Masaki; Cattoretti, Giorgio; McKeag, Lisa et al. (2006) Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development. J Immunol 176:3958-65
Liang, Xiquan; Hajivandi, Mahbod; Veach, Darren et al. (2006) Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells. Proteomics 6:4554-64
Janas, Justyna; Skowronski, Jacek; Van Aelst, Linda (2006) Lentiviral delivery of RNAi in hippocampal neurons. Methods Enzymol 406:593-605
Zhao, Mingming; Janas, Justyna A; Niki, Masaru et al. (2006) Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. Mol Cell Biol 26:2479-89
Oki, Shinji; Limnander, Andre; Yao, Pin Mei et al. (2005) Dok1 and SHIP act as negative regulators of v-Abl-induced pre-B cell transformation, proliferation and Ras/Erk activation. Cell Cycle 4:310-4
Wolff, Nicholas C; Veach, Darren R; Tong, William P et al. (2005) PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia. Blood 105:3995-4003

Showing the most recent 10 out of 37 publications