Core A is functionally the administration and clinical research support Core which will provide essential support for all administrative activities and clinical trial-associated activities of this Program Project Grant (PPG). The administrative components of the Core will provide support for accounting, budgeting, fiscal reporting and communication while the clinical research support components will facilitate protocol activation and execution as well as effective dissemination of information between program sites (ie Adult BMT Clinical Units on the University Campus and Pediatric BMT Clinical Units on the Riverside Campus). Clinical research support activities will include preparation and distribution of protocol revisions, research sample calendar monitoring, collection, tracking and distribution to research laboratory sites as well as monitoring supply procurement and distribution for centrally purchased materials needed for the clinical trials. The Core responsibilities will also include protocol monitoring and communication among project and Core key personnel through in-person meetings, regularly scheduled conference calls, and additional telephone communication. Additionally, the Core will support scheduling and coordination of internal research meetings and external consultant visits. This Core will be led by Dr. John Wagner.
The Specific Aims of the Core are to provide administrative support, scientific oversight, clinical oversight and promote PPG interactions and collaborations.

Public Health Relevance

The administration and clinical research support Core will provide essential support for all administrative activities and clinical trials associated with the program project grant. The administrative components of the Core will provide support for accounting, budgeting, fiscal reporting and communication while the clinical research support components will facilitate protocol activation and execution as well as effective dissemination of information between clinical sites. Optimization of infrastructural support, improved integration from multiple sources and timely and complete collection of planned blood and tissue samples for proposed laboratory evaluations will accelerate discovery, ultimately improving the health of the patients with high risk malignancy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA065493-24
Application #
9552724
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
24
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Hippen, Keli L; Loschi, Michael; Nicholls, Jemma et al. (2018) Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease. Front Immunol 9:57
Pennell, Christopher A; Barnum, Jessie L; McDonald-Hyman, Cameron S et al. (2018) Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice. Mol Ther 26:1423-1434
Williams, Shelly M; Sumstad, Darin; Kadidlo, Diane et al. (2018) Clinical-scale production of cGMP compliant CD3/CD19 cell-depleted NK cells in the evolution of NK cell immunotherapy at a single institution. Transfusion 58:1458-1467
Mathew, Nimitha R; Baumgartner, Francis; Braun, Lukas et al. (2018) Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med 24:282-291
Romee, Rizwan; Cooley, Sarah; Berrien-Elliott, Melissa M et al. (2018) First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation. Blood 131:2515-2527
Stefanski, Heather E; Jonart, Leslie; Goren, Emily et al. (2018) A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression. PLoS One 13:e0193461
Owen, David L; Mahmud, Shawn A; Vang, Kieng B et al. (2018) Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis. J Immunol 200:3926-3933
Osborn, Mark J; Lees, Christopher J; McElroy, Amber N et al. (2018) CRISPR/Cas9-Based Cellular Engineering for Targeted Gene Overexpression. Int J Mol Sci 19:
Oh, Felix; Todhunter, Deborah; Taras, Elizabeth et al. (2018) Targeting EGFR and uPAR on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin. Clin Pharmacol 10:113-121
Rashidi, Armin; Ebadi, Maryam; Said, Bassil et al. (2018) Absence of early HHV-6 reactivation after cord blood allograft predicts powerful graft-versus-tumor effect. Am J Hematol :

Showing the most recent 10 out of 395 publications