Abstract

Our overall objective is to continue to develop and implement high performance computer integration of pre-operative MR and CT data with intra-operative images in order to guide surgery intra-operatively. We will consolidate existing high performance computational hardware, networking facilities, segmentation and registration software, and develop user friendly interactive image processing software, for a system which can provide online, easily utilized information to surgeons during the execution of operative procedures. In order to accomplish these goals we will build enhancements to our existing systems for operator controlled segmentation (OCS), signal intensity-based segmentation (SIS) and template-driven segmentation (TDS). In addition, we will extend mutual information based (MI) rigid registration in various directions, with specific developments for use by applications in interventional MRI. We will also develop capabilities for non-rigid shape modeling and develop aggressive implementations of our basic non-rigid warping system. In order to test our image processing tools, we will build and utilize a validation database of cases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA067165-05
Application #
6496919
Study Section
Project Start
2001-05-01
Project End
2002-04-30
Budget Start
Budget End
Support Year
5
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Behringer, Peter A; Herz, Christian; Penzkofer, Tobias et al. (2016) Open-Source Platform for Prostate Motion Tracking During in-Bore Targeted MRI-Guided Biopsy. Clin Image Based Proced 9401:122-129
Tauscher, Sebastian; Tokuda, Junichi; Schreiber, Günter et al. (2015) OpenIGTLink interface for state control and visualisation of a robot for image-guided therapy systems. Int J Comput Assist Radiol Surg 10:285-92
Penzkofer, Tobias; Tuncali, Kemal; Fedorov, Andriy et al. (2015) Transperineal in-bore 3-T MR imaging-guided prostate biopsy: a prospective clinical observational study. Radiology 274:170-80
Yamauchi, Fernando I; Penzkofer, Tobias; Fedorov, Andriy et al. (2015) Prostate cancer discrimination in the peripheral zone with a reduced field-of-view T(2)-mapping MRI sequence. Magn Reson Imaging 33:525-30
Tempany, Clare M C; Jayender, Jagadeesan; Kapur, Tina et al. (2015) Multimodal imaging for improved diagnosis and treatment of cancers. Cancer 121:817-27
Kato, Takahisa; Okumura, Ichiro; Song, Sang-Eun et al. (2015) Tendon-Driven Continuum Robot for Endoscopic Surgery: Preclinical Development and Validation of a Tension Propagation Model. IEEE ASME Trans Mechatron 20:2252-2263
Tie, Yanmei; Rigolo, Laura; Ozdemir Ovalioglu, Aysegul et al. (2015) A New Paradigm for Individual Subject Language Mapping: Movie-Watching fMRI. J Neuroimaging 25:710-20
Langs, Georg; Sweet, Andrew; Lashkari, Danial et al. (2014) Decoupling function and anatomy in atlases of functional connectivity patterns: language mapping in tumor patients. Neuroimage 103:462-75
Penzkofer, Tobias; Tempany-Afdhal, Clare M (2014) Prostate cancer detection and diagnosis: the role of MR and its comparison with other diagnostic modalities--a radiologist's perspective. NMR Biomed 27:3-15
Jayender, Jagadaeesan; Chikarmane, Sona; Jolesz, Ferenc A et al. (2014) Automatic segmentation of invasive breast carcinomas from dynamic contrast-enhanced MRI using time series analysis. J Magn Reson Imaging 40:467-75

Showing the most recent 10 out of 187 publications