Prostate cancer represents one of the most significant challenges in medicine and public health, facing theUS healthcare system today. Its increased diagnosis has lead to a virtual 'epidemic of this disease. MRI isuniquely suited to imaging the prostate as it allows excellent visualization of the gland, its boundary,substructure and all surrounding tissues. We have developed both a MR-guided prostate brachytherapy andbiopsy program, which utilizes the open 0.5T interventional MRT system.We propose to adapt and translate these programs to meet the major advantages offered by high-field MRI(3T). In the proposed research we plan to apply an interactive comprehensive MR image- guided programfor the diagnosis and treatment of localized prostate cancer. This integrated system will allow preoperativeand intraoperative MR images of the prostate to be available on-line in the operating room.The challenge is to increase the information content of intraoperative image data by using multimodalfeatures while at the same time preserving the interactivity and the near-real time features of intraoperativeimaging, in a closed bore high-field system. But if this can be achieved the precise delivery of treatment tomaximize tumor control, and minimize side effects will be achieved and will improve the patients quality oflife after treatment.
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