) The objective of the projects in this application is to improve the therapeutic results for patients with ALL. Acquisition of specimens with leukemic cells is critical to the success of the basic science projects (Projects 6, 7, and 8). The projects that involve translational research objectives (Projects 5, 9 and 10) require access to serial bone marrow and peripheral blood specimens from patients as well as accurate and complete information on the long-term clinical outcomes of these patients. The coordinating center functions provided by this core are essential for the successful conduct of the multi-center clinical trial, the acquisition and distribution of patient specimens, data computerization and quality control, and follow-up of patients on studies of cardiac function, neuropsychological sequelae and quality of life (Project 4). Biostatistical collaboration is also essential for the proper design, conduct, analysis and reporting of the research studies. The purpose of this Biostatistics and Research Support Core is to provide the following services that will be utilized by all of the research projects: 1) to collect research specimens and coordinate patient follow-up at DFCI; 2) to coordinate the collection of research specimens and follow-up data from consortium centers; 3) to ensure that study parameters are followed and confirm eligibility and patient registration; 4) to ensure accuracy of submitted data from consortium institutions (including conduct of on-site audits); 5) to provide biostatistical collaboration for laboratory, translational and clinical research projects (including all aspects of the design, conduct, analysis, and reporting of the studies, and the direction of data processing and data quality control assurance); 6) to provide data management for the collection of individual patient information and data from research laboratories; 7) to provide a biomedical data coordinator to maintain a computerized database, with assured quality control and standardized reporting; 8) to provide computing resources for data processing, forms design and statistical analyses; 9) to provide web-based communication for study team and consortium members with secured access, and maintain an internet web-site for patient education; 10) to coordinate functions of the Data Monitoring Committee.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA068484-08
Application #
6654039
Study Section
Project Start
2002-09-01
Project End
2003-04-30
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Lipshultz, Steven E (2018) Letter by Lipshultz Regarding Article, ""Anthracycline Cardiotoxicity: Worrisome Enough to Have You Quaking?"" Circ Res 122:e62-e63
Bansal, Neha; Barach, Paul; Amdani, Shahnawaz M et al. (2018) When is early septal myectomy in children with hypertrophic cardiomyopathy justified? Transl Pediatr 7:362-366
Mansour, Marc R; He, Shuning; Li, Zhaodong et al. (2018) JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med 215:1929-1945
Temple, Jennifer L; Bernard, Christophe; Lipshultz, Steven E et al. (2017) The Safety of Ingested Caffeine: A Comprehensive Review. Front Psychiatry 8:80
Rahman, Sunniyat; Magnussen, Michael; León, Theresa E et al. (2017) Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. Blood 129:3221-3226
Hutchins, Kelley K; Siddeek, Hani; Franco, Vivian I et al. (2017) Prevention of cardiotoxicity among survivors of childhood cancer. Br J Clin Pharmacol 83:455-465
Bona, Kira; Blonquist, Traci M; Neuberg, Donna S et al. (2016) Impact of Socioeconomic Status on Timing of Relapse and Overall Survival for Children Treated on Dana-Farber Cancer Institute ALL Consortium Protocols (2000-2010). Pediatr Blood Cancer 63:1012-8
Seftel, Matthew D; Neuberg, Donna; Zhang, Mei-Jie et al. (2016) Pediatric-inspired therapy compared to allografting for Philadelphia chromosome-negative adult ALL in first complete remission. Am J Hematol 91:322-9
Fraser, Raphael André; Lipsitz, Stuart R; Sinha, Debajyoti et al. (2016) Approximate median regression for complex survey data with skewed response. Biometrics 72:1336-1347
Lipshultz, Steven E; Anderson, Lynn M; Miller, Tracie L et al. (2016) Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin-treated childhood acute lymphoblastic leukemia survivors. Cancer 122:946-53

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