Abstract

) This Core will direct GCT (germ cell tumor) sample distribution to each of the four individual projects. It will do this in three ways. First, surgical GCT specimens will be obtained by one of the co-investigators who is responsible for the orchiectomies and retroperitoneal lymph node dissections here. One hundred-nineteen such procedures took place in 1996, most supervised by this team of investigators. Second, the Project Leader, a pathologist, will dissect away the normal tissue. Third, the Core will distribute the tissue to the individual projects. In summary, this Core will facilitate transfer of GCT specimens to the molecular and cellular investigators who need them.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA074295-02
Application #
6336445
Study Section
Project Start
2000-08-01
Project End
2001-07-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
$86,226
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Juric, Dejan; Sale, Sanja; Hromas, Robert A et al. (2005) Gene expression profiling differentiates germ cell tumors from other cancers and defines subtype-specific signatures. Proc Natl Acad Sci U S A 102:17763-8
George, David W; Foster, Richard S; Hromas, Robert A et al. (2003) Update on late relapse of germ cell tumor: a clinical and molecular analysis. J Clin Oncol 21:113-22
Madani, A; Kemmer, K; Sweeney, C et al. (2003) Expression of KIT and epidermal growth factor receptor in chemotherapy refractory non-seminomatous germ-cell tumors. Ann Oncol 14:873-80
Guo, Ying; Costa, Robert; Ramsey, Heather et al. (2002) The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Proc Natl Acad Sci U S A 99:3663-7
Soule, S; Baldridge, L; Kirkpatrick, K et al. (2002) HER-2/neu expression in germ cell tumours. J Clin Pathol 55:656-8
Richkind, K; Hromas, R; Lytle, C et al. (2000) Identification of two new translocations that disrupt the AML1 gene. Cancer Genet Cytogenet 122:141-3
Hromas, R; Shopnick, R; Jumean, H G et al. (2000) A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations. Blood 95:4011-3