Abstract

The Assay Services Core will make available to participating investigators the resources of the University of Michigan Research Assay Support Laboratory (RASL), a reference laboratory for nicotine/cotinine HPLC analysis. Projects 1,2, and 3 will make extensive use of the nicotine/cotinine assay, for venous and (in the case of Project 1) arterial samples. Project 2 will also include assays for plasma cortisol, caffeine, and methylphenidate. Project 3 requires the preparation and purification of a nicotine bitartrate solution for administration via an intranasal nicotine aerosol delivery device. PCR-based DNA analyses to determine twin zygosity will be provided for Projects 3 and 4. Plasma samples for cotinine analyses to characterize nicotine intake from usual smoking will be analyzed for all smokers, and blood samples will be obtained from all subjects and stored for subsequent DNA analyses to determine genetic influences on nicotine dependence.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA075581-04
Application #
6325784
Study Section
Project Start
2000-07-01
Project End
2002-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
2000
Total Cost
$100,568
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Brigham, Janet; Lessov-Schlaggar, Christina N; Javitz, Harold S et al. (2010) Validity of recall of tobacco use in two prospective cohorts. Am J Epidemiol 172:828-35
Brigham, Janet; Lessov-Schlaggar, Christina N; Javitz, Harold S et al. (2009) Test-retest reliability of web-based retrospective self-report of tobacco exposure and risk. J Med Internet Res 11:e35
Javitz, Harold S; Brigham, Janet; Lessov-Schlaggar, Christina N et al. (2009) Association of tobacco dependence and quit attempt duration with Rasch-modeled withdrawal sensitivity using retrospective measures. Addiction 104:1027-35
Brigham, Janet; Lessov-Schlaggar, Christina N; Javitz, Harold S et al. (2008) Reliability of adult retrospective recall of lifetime tobacco use. Nicotine Tob Res 10:287-99
Kuo, Po-Hsiu; Wood, Philip; Morley, Katherine I et al. (2007) Cohort trends in prevalence and spousal concordance for smoking. Drug Alcohol Depend 88:122-9
Morley, Katherine I; Lynskey, Michael T; Madden, Pamela A F et al. (2007) Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment? Psychol Med 37:1357-67
Hottenga, Jouke-Jan; Whitfield, John B; Posthuma, Danielle et al. (2007) Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q, and 17P. Hypertension 49:832-8
Morley, Katherine I; Medland, Sarah E; Ferreira, Manuel Ar et al. (2006) A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families. Behav Genet 36:87-99
Hudmon, Karen Suchanek; Pomerleau, Cynthia S; Brigham, Janet et al. (2005) Validity of retrospective assessments of nicotine dependence: a preliminary report. Addict Behav 30:613-7
Madden, Pamela A F; Pedersen, Nancy L; Kaprio, Jaakko et al. (2004) The epidemiology and genetics of smoking initiation and persistence: crosscultural comparisons of twin study results. Twin Res 7:82-97

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