Abstract

The goal of the Cell Analysis Core is to provide support for those investigators studying the cellular biology of normal and metastatic prostate tumor cells. The analysis of cell structure, cell movement and cell dynamics are important components of each of the research projects described in this Program Project. In addition the ability the ability to detect the expression of macromolecules in individual cells and in tissue samples is key to the success of all of the projects. Therefore, the Core will seek to provide instrumentation and technical support to accomplish these objectives.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA076465-01A2
Application #
6260120
Study Section
Subcommittee G - Education (NCI)
Project Start
1999-04-01
Project End
2004-01-31
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Axelrod, Mark J; Mendez, Rolando E; Khalil, Ashraf et al. (2015) Synergistic apoptosis in head and neck squamous cell carcinoma cells by co-inhibition of insulin-like growth factor-1 receptor signaling and compensatory signaling pathways. Head Neck 37:1722-32
DaSilva, John O; Amorino, George P; Casarez, Eli V et al. (2013) Neuroendocrine-derived peptides promote prostate cancer cell survival through activation of IGF-1R signaling. Prostate 73:801-12
Gioeli, Daniel; Wunderlich, Winfried; Sebolt-Leopold, Judith et al. (2011) Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer. Mol Cancer Ther 10:1581-90
Vomastek, Tomas; Iwanicki, Marcin P; Burack, W Richard et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol 28:6954-66
Casarez, Eli V; Dunlap-Brown, Marya E; Conaway, Mark R et al. (2007) Radiosensitization and modulation of p44/42 mitogen-activated protein kinase by 2-Methoxyestradiol in prostate cancer models. Cancer Res 67:8316-24
Deeble, Paul D; Cox, Michael E; Frierson Jr, Henry F et al. (2007) Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells. Cancer Res 67:3663-72
Gioeli, Daniel; Black, Ben E; Gordon, Vicki et al. (2006) Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization. Mol Endocrinol 20:503-15
Gioeli, Daniel (2005) Signal transduction in prostate cancer progression. Clin Sci (Lond) 108:293-308
Fu, Maofu; Rao, Mahadev; Wu, Kongming et al. (2004) The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. J Biol Chem 279:29436-49
Cooper, Carlton R; Sikes, Robert A; Nicholson, Brian E et al. (2004) Cancer cells homing to bone: the significance of chemotaxis and cell adhesion. Cancer Treat Res 118:291-309

Showing the most recent 10 out of 20 publications