Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA077738-02
Application #
6420523
Study Section
Subcommittee G - Education (NCI)
Project Start
2001-03-01
Project End
2002-02-28
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$151,297
Indirect Cost
Name
Thomas Jefferson University
Department
Type
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Nana-Sinkam, S Patrick; Croce, Carlo M (2014) MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use. Genome Biol 15:445
Saldivar, Joshua C; Bene, Jessica; Hosseini, Seyed Ali et al. (2013) Characterization of the role of Fhit in suppression of DNA damage. Adv Biol Regul 53:77-85
Huebner, Kay; Saldivar, Joshua C; Sun, Jin et al. (2011) Hits, Fhits and Nits: beyond enzymatic function. Adv Enzyme Regul 51:208-17
Cirombella, Roberto; Montrone, Giuseppe; Stoppacciaro, Antonella et al. (2010) Fhit loss in lung preneoplasia: relation to DNA damage response checkpoint activation. Cancer Lett 291:230-6
Sun, Jin; Okumura, Hiroshi; Yearsley, Martha et al. (2009) Nit1 and Fhit tumor suppressor activities are additive. J Cell Biochem 107:1097-106
Pichiorri, Flavia; Okumura, Hiroshi; Nakamura, Tatsuya et al. (2009) Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. J Biol Chem 284:1040-9
Ishii, Hideshi; Mimori, Koshi; Ishikawa, Kazuhiro et al. (2008) Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes. Cancer Res 68:3662-70
Iliopoulos, Dimitrios; Fabbri, Muller; Druck, Teresa et al. (2007) Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression. Clin Cancer Res 13:268-74
Semba, Shuho; Huebner, Kay (2006) Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression. Mol Cancer Res 4:529-38
Semba, Shuho; Han, Shuang-Yin; Qin, Haiyan R et al. (2006) Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. J Biol Chem 281:28244-53

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