Abstract

This core is developed to meet the need for morphological, histological and cytological screening of new mouse mutants produced by Core B for all Projects of this proposal. Because a number of such genetically manipulated mice will be created and because those generating the mice are in most cases not trained in all aspects of mouse physiology and histology, a core facility is necessary to insure that all phenotypes are accurately identified. Quality control procedures will be implemented to ensure reliability and consistency in the analyses. The core will be supervised by Dr. Makio Ogawa, who is a board certified hematologist and experienced in the development of mouse hematopoietic systems. In addition. Dr. Sarah Bingel (Veterinary Pathologist) of MUSC, will be in charge of analyzing the tissue and organ samples.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA078582-02
Application #
6203466
Study Section
Project Start
1999-08-25
Project End
2000-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425

  Publications

Scheiber, Melissa N; Watson, Patricia M; Rumboldt, Tihana et al. (2014) FLI1 expression is correlated with breast cancer cellular growth, migration, and invasion and altered gene expression. Neoplasia 16:801-13
Kornblau, Steven M; Qiu, Yi Hua; Zhang, Nianxiang et al. (2011) Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia. Blood 118:5604-12
Turner, David P; Findlay, Victoria J; Moussa, Omar et al. (2011) Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression. Prostate 71:1723-35
Markiewicz, Margaret; Nakerakanti, Sashidhar S; Kapanadze, Bagrat et al. (2011) Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells. Microcirculation 18:1-11
Findlay, Victoria J; Turner, David P; Yordy, John S et al. (2011) Prostate-Derived ETS Factor Regulates Epithelial-to-Mesenchymal Transition through Both SLUG-Dependent and Independent Mechanisms. Genes Cancer 2:120-9
Duchi, Serena; Fagnocchi, Luca; Cavaliere, Valeria et al. (2010) Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability. Development 137:1493-503
Asano, Yoshihide; Stawski, Lukasz; Hant, Faye et al. (2010) Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol 176:1983-98
Moussa, Omar; LaRue, Amanda C; Abangan Jr, Romeo S et al. (2010) Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol 30:5194-206
Elkareh, Jihad; Periyasamy, Sankaridrug M; Shidyak, Amjad et al. (2009) Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy. Am J Physiol Renal Physiol 296:F1219-26
Shirai, Keisuke; Sera, Yasuhiko; Bulkeley, William et al. (2009) Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia. Exp Hematol 37:1464-71

Showing the most recent 10 out of 84 publications