Core component B will grow human xenograft tumors selected by Project 1 and conduct standard high-dose rate and low-dose-rate therapies, and measure the resulting regrowth delays. The results will be used by Project 1 to test hypotheses concerning how the time-course of irradiation interacts with characteristics of different tumor cell lines to determine tumor responses. The standard high-dose-rate therapies will be a single 10 Gy fraction or two fractionated protocols in which most radiation is given either early or late in the treatment. The standard low-doze treatments will be made with either one or two injections of 125I-labeled immunomicrospheres prepared by Project 3 to meet the treatment conditions required by Project 1. Later in the project, high- and low-dose rate treatments will be used in combination. Core B will monitor tumor retention by trace-labeling the preparations with 131I and using an external detector. Tumor dose rate distributions produced by the injections will be measured using radiochromic medium. Based on these measurements, Core B will work with project 1 to calculate how the resulting dose patterns and different models of cellular sensitivity would affect tumor response. Core B will also grow tumors and make the necessary injections for hypoxia measurements to be made by Project 2.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA079862-01A1
Application #
6135301
Study Section
Project Start
1999-07-01
Project End
2000-04-30
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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