Abstract

The overall long-term objective of this Program Project is to identify novel dietary and hormonal determinants of breast colorectal and ovarian cancer risk in women, with the ultimate aim to find means for prevention and improved survival. The combination of questionnaire derived data with biomarkers, coupled with the long-follow-up, affords the opportunity to further understanding of the time course and mechanisms of cancer development. To achieve these objectives, we will relate a) prospectively collected data on diet, post-menopausal hormone use, smoking, and other behaviors; b) nutrient and hormone levels in prospectively collected blood; and c) genotyping information form archived DNA and tissue blocks; to incidence of breast colorectal, and ovarian cancer. This Program Project is based on the Nurses' Health Study cohort comprising 1212,700 women who were 30 to 55 years of age when enrolled in 1976. The Program Project serves as the central resource for the many related grants addressing incidence of cancer and other major chronic diseases that arise in this cohort of women. Project 1. Diet, exogenous hormones and breast cancer risk. Project 2. Diet, hormones and brisk of colorectal cancer. Project 3. Hormones, diet and risk of ovarian cancer. Project 4. Statistical innovations in risk modeling.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA087969-03
Application #
6475805
Study Section
Special Emphasis Panel (ZCA1-GRB-A (M1))
Program Officer
Hartmuller, Virginia W
Project Start
2000-09-12
Project End
2004-11-30
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
3
Fiscal Year
2002
Total Cost
$3,794,684
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Gaudet, Mia M; Gierach, Gretchen L; Carter, Brian D et al. (2018) Pooled Analysis of Nine Cohorts Reveals Breast Cancer Risk Factors by Tumor Molecular Subtype. Cancer Res 78:6011-6021
Zhang, Xuehong; Rice, Megan; Tworoger, Shelley S et al. (2018) Addition of a polygenic risk score, mammographic density, and endogenous hormones to existing breast cancer risk prediction models: A nested case-control study. PLoS Med 15:e1002644
Cao, Yin; Wu, Kana; Mehta, Raaj et al. (2018) Long-term use of antibiotics and risk of colorectal adenoma. Gut 67:672-678
Khalaf, Natalia; Yuan, Chen; Hamada, Tsuyoshi et al. (2018) Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies. Gastroenterology 154:1380-1390.e5
Kensler, Kevin H; Beca, Francisco; Baker, Gabrielle M et al. (2018) Androgen receptor expression in normal breast tissue and subsequent breast cancer risk. NPJ Breast Cancer 4:33
Heng, Yujing J; Wang, Jun; Ahearn, Thomas U et al. (2018) Molecular mechanisms linking high body mass index to breast cancer etiology in post-menopausal breast tumor and tumor-adjacent tissues. Breast Cancer Res Treat :
Farvid, Maryam S; Chen, Wendy Y; Rosner, Bernard A et al. (2018) Fruit and vegetable consumption and breast cancer incidence: Repeated measures over 30 years of follow-up. Int J Cancer :
Li, Jun; Rice, Megan S; Huang, Tianyi et al. (2018) Circulating prolactin concentrations and risk of type 2 diabetes in US women. Diabetologia 61:2549-2560
O'Mara, Tracy A; Glubb, Dylan M; Amant, Frederic et al. (2018) Identification of nine new susceptibility loci for endometrial cancer. Nat Commun 9:3166
Tabung, Fred K; Wang, Weike; Fung, Teresa T et al. (2018) Association of dietary insulinemic potential and colorectal cancer risk in men and women. Am J Clin Nutr 108:363-370

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