In this Project, we propose to continue the investigation of potentially modifiable nutritional and hormonal risk factors for incident ovarian cancer. This work will use prospectively collected questionnaire data, biological samples, and paraffin-embedded ovarian tumor tissue from women in the Nurses'Health Study (NHS) and NHSII. Although several hypotheses regarding ovarian cancer etiology have been proffered, few modifiable lifestyle risk factors have been identified. We will examine the possible preventive role of vitamin D in ovarian cancer, with the goal of identifying subpopulations who could most benefit from intervention. We also will evaluate three dietary factors: flavonoids, which may reduce risk;lactose in adolescence and adulthood;and acrylamide intake and red blood cell adduct levels, both of which may increase risk. We also will evaluate the role of melatonin and shift work in ovarian carcinogenesis. In addition, we propose to measure circulating markers of inflammation (CPR, IL-6, and TNFa-R2) and tumor markers associated with inflammation (e.g., STATs). We also propose for the first time to focus specifically on fatal ovarian cancer, with an effort to identify risk factors that may predispose women to either having fast-growing tumors or a peritoneal environment susceptible to metastasis. In this same vein, we plan to evaluate hormone receptors in ovarian tumors and their relation to risk factors, with an emphasis on exploring a new model of ovarian carcinogenesis (slow-growing tumors vs. fast-growing tumors) as a way to classify tumors in epidemiologic studies. The Project shares common biological themes with Projects 1 and 2, including the role of vitamin D, melatonin, and the inflammation pathway and interacts closely with Project 4 for methodologic issues. It also shares with the other Projects a strong administrative and scientific infrastructure provided by Cores A (cohort follow-up and data base maintenance), B (confirmation of cancer and cause of death), C (management of the biospecimens) and D (leadership and data analysis). The findings should enhance understanding of the etiology and progression of ovarian cancer and provide guidance for women and their health care providers in their efforts to reduce suffering and death from this disease.
It is difficult to diagnose ovarian cancer, so improving prevention is key for reducing morbidity and mortality. This proposal examines potential preventive agents (vitamin D, melatonin, flavonoids) and risk factors (shiftwork, lactose, acrylamide). Another emphasis is on ovarian etiology (inflammation, hormones), which could lead to better diagnostic and treatment tools, and a focus on risk factors for fatal ovarian cancer.
| Beattie, J Renwick; Feskanich, Diane; Caraher, M Clare et al. (2018) A Preliminary Evaluation of the Ability of Keratotic Tissue to Act as a Prognostic Indicator of Hip Fracture Risk. Clin Med Insights Arthritis Musculoskelet Disord 11:1179544117754050 |
| Theofylaktopoulou, Despoina; Midttun, Øivind; Ueland, Per M et al. (2018) Impaired functional vitamin B6 status is associated with increased risk of lung cancer. Int J Cancer 142:2425-2434 |
| Rice, Megan S; Rist, Pamela M; Winter, Anke C et al. (2018) Migraine and invasive epithelial ovarian cancer risk in the Nurses' Health Study II and the Women's Health Study. Int J Cancer 142:534-539 |
| Liu, Li; Nevo, Daniel; Nishihara, Reiko et al. (2018) Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol 33:381-392 |
| Van Dyke, Alison L; Langhamer, Margaret S; Zhu, Bin et al. (2018) Family History of Cancer and Risk of Biliary Tract Cancers: Results from the Biliary Tract Cancers Pooling Project. Cancer Epidemiol Biomarkers Prev 27:348-351 |
| Hirko, Kelly A; Chai, Boyang; Spiegelman, Donna et al. (2018) Erythrocyte membrane fatty acids and breast cancer risk: a prospective analysis in the nurses' health study II. Int J Cancer 142:1116-1129 |
| Bronson, Mackenzie R; Kapadia, Nirav S; Austin, Andrea M et al. (2018) Leveraging Linkage of Cohort Studies With Administrative Claims Data to Identify Individuals With Cancer. Med Care 56:e83-e89 |
| Simon, Tracey G; King, Lindsay Y; Chong, Dawn Q et al. (2018) Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies. Hepatology 67:1797-1806 |
| Trudel-Fitzgerald, Claudia; Tworoger, Shelley S; Poole, Elizabeth M et al. (2018) Psychological symptoms and subsequent healthy lifestyle after a colorectal cancer diagnosis. Health Psychol 37:207-217 |
| Graff, Rebecca E; Ahearn, Thomas U; Pettersson, Andreas et al. (2018) Height, Obesity, and the Risk of TMPRSS2:ERG-Defined Prostate Cancer. Cancer Epidemiol Biomarkers Prev 27:193-200 |
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