Abstract

The purpose of the Biostatistics and Clinical Trials Core (Core C) is to provide biostatistical collaboration and support for the projects in this Program Project, and to provide the clinical research infrastructure needed to support the investigations of Project 4 and any translational clinical trials which arise from the projects.
The specific aims of Core D are: 1. To provide statistical support for design and analysis of murine experiments conducted in Projects 1, 2, 3, and 5. 2. To provide statistical support for the design and analysis of laboratory experiments conducted in Projects 4 and 5, in conjunction with Cores A and B, including the correlation of laboratory results and clinical outcomes. 3. To provide statistical support for translational clinical research studies using candidate target inhibitors from the discoveries of Projects 4 and 5. 4. To provide clinical research infrastructure for translational clinical research studies using candidate target inhibitors from the discoveries of Projects 4 and 5.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA092625-08
Application #
7726922
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
8
Fiscal Year
2008
Total Cost
$173,108
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Chapuy, Bjoern; Cheng, Hongwei; Watahiki, Akira et al. (2016) Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease. Blood 127:2203-13
Zhang, Baochun; Calado, Dinis Pedro; Wang, Zhe et al. (2015) An oncogenic role for alternative NF-?B signaling in DLBCL revealed upon deregulated BCL6 expression. Cell Rep 11:715-26
Carey, Christopher D; Gusenleitner, Daniel; Chapuy, Bjoern et al. (2015) Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. J Mol Diagn 17:19-30
Gostissa, Monica; Bianco, Julia M; Malkin, Daniel J et al. (2013) Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proc Natl Acad Sci U S A 110:2934-9
Yan, Qingsheng; Xu, Rong; Zhu, Liya et al. (2013) BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Mol Cell Biol 33:845-57
Ying, Carol Y; Dominguez-Sola, David; Fabi, Melissa et al. (2013) MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma. Nat Immunol 14:1084-92
Chen, Linfeng; Monti, Stefano; Juszczynski, Przemyslaw et al. (2013) SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas. Cancer Cell 23:826-38
Rossi, Davide; Rasi, Silvia; Spina, Valeria et al. (2013) Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 121:1403-12
Brown, Jennifer R; Hanna, Megan; Tesar, Bethany et al. (2012) Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia. Clin Cancer Res 18:3791-802
Lohr, Jens G; Stojanov, Petar; Lawrence, Michael S et al. (2012) Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A 109:3879-84

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