The Synthetic Chemistry Core facility will provide four basic services to this Program Project Grant (PPG).First, it will assist in the selection, prioritization and validation of primary hits identified from the efforts of theHTS Core for further chemical development. Second, the Core will provide synthetic servicesto includestructure-activity relationship (SAR) studies, scale-up of small molecules of interest for further pre-clinicalevaluation, synthesis of labeled compounds (isotopes, radioisotopes, and affinity labels), in addition togeneral synthetic services for intermediates and reagents not commerciallyavailable. A third service that willencompass the Synthetic Chemistry Core will be to provide analytical chemistry support to assist incompound identification, stability and solubility studies, metabolite identification (in collaboration with thePreclinical Pharmacology Core) and compound purity analysis. Finally, a continuous goal of the Core will beto establish a UTSW Compound Repository for the characterization, collection and submission of drug-likeintermediates and analogs synthesized by the Core for inclusion into the current HTS screening library tofuther enhance our library diversity.
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