Abstract

The Tumor/Cell Biology and Histology Core (Core C) will have the following functions: 1) maintain inventory of cell lines, 2) expand tumor cells for implantation into animal subjects, 3) perform necropsies, routine histology and immunohistochemistry on tissues, 4) prepare spleenocytes and hepatocytes for in vitro cytolytic CTL assays, 5) analyze prostate biopsies for therapeutic gene expression, and 6) monitor neutralizing antibodies to adenovirus in patient's serum.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA097012-01A2
Application #
6990182
Study Section
Subcommittee G - Education (NCI)
Project Start
2004-08-01
Project End
2009-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
1
Fiscal Year
2004
Total Cost
$105,165
Indirect Cost

  Institution

Name
Henry Ford Health System
Department
Type
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Freytag, Svend O; Stricker, Hans; Lu, Mei et al. (2014) Prospective randomized phase 2 trial of intensity modulated radiation therapy with or without oncolytic adenovirus-mediated cytotoxic gene therapy in intermediate-risk prostate cancer. Int J Radiat Oncol Biol Phys 89:268-76
Lu, Mei; Freytag, Svend O; Stricker, Hans et al. (2011) Adaptive seamless design for an efficacy trial of replication-competent adenovirus-mediated suicide gene therapy and radiation in newly-diagnosed prostate cancer (ReCAP Trial). Contemp Clin Trials 32:453-60
Barton, Kenneth N; Stricker, Hans; Elshaikh, Mohamed A et al. (2011) Feasibility of adenovirus-mediated hNIS gene transfer and 131I radioiodine therapy as a definitive treatment for localized prostate cancer. Mol Ther 19:1353-9
Kumar, Sanath; Freytag, Svend O; Barton, Kenneth N et al. (2010) A novel method of boron delivery using sodium iodide symporter for boron neutron capture therapy. J Radiat Res 51:621-6
Siddiqui, Farzan; Kolozsvary, Andrew; Barton, Kenneth N et al. (2009) Does hyperthermia increase adenoviral transgene expression or dissemination in tumors? Int J Hyperthermia 25:273-9
Freytag, Svend O; Stricker, Hans; Peabody, James et al. (2007) Five-year follow-up of trial of replication-competent adenovirus-mediated suicide gene therapy for treatment of prostate cancer. Mol Ther 15:636-42
Freytag, Svend O; Barton, Kenneth N; Brown, Stephen L et al. (2007) Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer. Mol Ther 15:1600-6
Brown, Stephen L; Freytag, Svend O; Barton, Kenneth N et al. (2007) Reporter gene imaging using radiographic contrast from nonradioactive iodide sequestered by the sodium-iodide symporter. Contrast Media Mol Imaging 2:240-7
Barton, Kenneth N; Freytag, Svend O; Nurushev, Teamour et al. (2007) A model for optimizing adenoviral delivery in human cancer gene therapy trials. Hum Gene Ther 18:562-72
Freytag, Svend O; Movsas, Benjamin; Aref, Ibrahim et al. (2007) Phase I trial of replication-competent adenovirus-mediated suicide gene therapy combined with IMRT for prostate cancer. Mol Ther 15:1016-23

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