The Radiolabeling, Quality Assurance, and Immunoassay Core will provide a variety of services for theparticipants of this Program Project. This Core Facility has been providing these same services to CMMIinvestigators for 20 years. The primary responsibility of this core involves the preparation of radiolabeledagents for investigators. This includes the processing, receipt, preparation, quality assurance and disposal ofthe radiolabeled materials. This laboratory has experience in preparing radiolabeled antibodies and peptideswith 1311,1251,123I, ' V 90Y, 188Re, 99mTc, 212Bi, and 67Ga. Each product that is produced undergoes a seriesof quality assurance checks, including ITLC, size-exclusion HPLC, and Immunoreactivity determinations.All equipment used in this laboratory is calibrated regularly and all procedures are performed under SOPs.This laboratory also produces radiolabeled investigational agents for a number of INDs, and has experiencein developing procedures to ensure product stability when shipped to extramural investigational sites. Thiscore is also involved in the processing of blood and urine samples used for pharmacokinetic analysis, as wellas plasma samples for anti-antibody assays. This Core will be utilized by Projects 1,2, and 4.
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