The objective of the Administrative Core is to promote, facilitate, coordinate and evaluate multidisciplinaryresearch. This Core is also designed to catalyze and enhance synergistic interactions among Cores and researchProjects. The Core has 4 Specific Aims:
Aim 1. Promote synergies, coordination and communication in Programmatic research:1.1. Organize regular scientific meetings and annual retreat of the faculty members, postdoctoral fellows,students and staff under the aegis of the Program to integrate and enhance Projects;1.2. Provide a state of the art interactive searchable database for procedure, reagent tracking andteaching (PROSTA).
Aim 2. Provide biostatistical support, quality control, teaching and develop specialized techniques as required byProjects and Cores.2.1. Provide on-going statistical support in the design and analysis of experiments.2.2. Development or application of novel statistical methodology.2.3. Provide Data Quality Control and Training in Statistical MethodsAim 3. Provide ongoing scientific evaluation of the Projects and Cores and the overall efficiency and costeffectiveness of the Program.The Program's Steering Committee chaired by Drs. Theodorescu, Weber and Conaway will meet monthlyto review the performance of all Projects and Cores. This will be complemented by yearly meetings withinternal and every other year with external advisors. The Administrative Core will be evaluated by directorsof Core units and Project Leaders.
Aim 4. Provide administrative support to tasks in Aim 1-3 as required by Program participants.
| Kuscu, Canan; Kumar, Pankaj; Kiran, Manjari et al. (2018) tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner. RNA 24:1093-1105 |
| Hao, Yi; Bjerke, Glen A; Pietrzak, Karolina et al. (2018) TGF? signaling limits lineage plasticity in prostate cancer. PLoS Genet 14:e1007409 |
| Yang, Chun-Song; Melhuish, Tiffany A; Spencer, Adam et al. (2017) The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. Prostate 77:1452-1467 |
| Kumar, Pankaj; Kuscu, Canan; Dutta, Anindya (2016) Biogenesis and Function of Transfer RNA-Related Fragments (tRFs). Trends Biochem Sci 41:679-689 |
| Agarwal, Neeraj; Dancik, Garrett M; Goodspeed, Andrew et al. (2016) GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis. Cancer Res 76:5175-85 |
| Reon, Brian J; Dutta, Anindya (2016) Biological Processes Discovered by High-Throughput Sequencing. Am J Pathol 186:722-32 |
| Sakurai, Kouhei; Reon, Brian J; Anaya, Jordan et al. (2015) The lncRNA DRAIC/PCAT29 Locus Constitutes a Tumor-Suppressive Nexus. Mol Cancer Res 13:828-38 |
| Dillon, Laura W; Kumar, Pankaj; Shibata, Yoshiyuki et al. (2015) Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity. Cell Rep 11:1749-59 |
| Kumar, Pankaj; Mudunuri, Suresh B; Anaya, Jordan et al. (2015) tRFdb: a database for transfer RNA fragments. Nucleic Acids Res 43:D141-5 |
| Earl, Julie; Rico, Daniel; Carrillo-de-Santa-Pau, Enrique et al. (2015) The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies. BMC Genomics 16:403 |
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