Abstract

The Murine Genetics Core is designed to provide centralized and specialized animal breeding and screening of several strains of mice. Breeding of immunodeficient and transgenic mice is required for the studies in all the projects. Many of the strains are not commercially available or are not readily available in numbers needed by the studies. These strains will be bred and genetically screened by the core. The core will also oversee the husbandry of the animals and periodically screen them to ensure that they are parasite free as well as virus and mycoplasma antibody free. In addition, the core will also provide screening services for the review of the many tumor cell lines which will be used in the various projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA109094-05
Application #
8258671
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
2013-03-31
Budget Start
2011-04-01
Budget End
2012-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$100,269
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146

  Publications

Wolf, Dietlinde; Barreras, Henry; Bader, Cameron S et al. (2017) Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 23:757-766
Schwartz, Marc; Zhang, Yu; Rosenblatt, Joseph D (2016) B cell regulation of the anti-tumor response and role in carcinogenesis. J Immunother Cancer 4:40
McCormack, Ryan M; Lyapichev, Kirill; Olsson, Melissa L et al. (2015) Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2. Elife 4:
McCormack, Ryan M; de Armas, Lesley R; Shiratsuchi, Motoaki et al. (2015) Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria. Elife 4:
Hatfield, Stephen M; Kjaergaard, Jorgen; Lukashev, Dmitriy et al. (2015) Immunological mechanisms of the antitumor effects of supplemental oxygenation. Sci Transl Med 7:277ra30
Newman, Robert G; Dee, Michael J; Malek, Thomas R et al. (2014) Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood 123:3045-55
Gonzalez, Louis; Strbo, Natasa; Podack, Eckhard R (2013) Humanized mice: novel model for studying mechanisms of human immune-based therapies. Immunol Res 57:326-34
McCormack, Ryan; de Armas, Lesley R; Shiratsuchi, Motoaki et al. (2013) Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1. J Innate Immun 5:185-94
Fields, K A; McCormack, R; de Armas, L R et al. (2013) Perforin-2 restricts growth of Chlamydia trachomatis in macrophages. Infect Immun 81:3045-54
McCormack, Ryan; de Armas, Lesley; Shiratsuchi, Motoaki et al. (2013) Killing machines: three pore-forming proteins of the immune system. Immunol Res 57:268-78

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