Core D - Phyllis GimottyThe Biostatistics Core consists of personnel with biostatistical experience. The goals of the BiostatisticsCore are to provide biostatistical expertise to program project investigators, and through collaboration usestatistical models and other statistical techniques to understand the critical abnormalities in signalingmolecules, pathways, and networks that are pathogenetic in melanoma and that have therapeuticrelevance. The Biostatistics Core faculty and staff have previous experience in melanoma research andextensive experience with the proposed statistical methodologies and their application to the researchstudies proposed in this program project. They will provide expertise in the following areas to support itsresearch objectives: (1) statistical methods to study associations among gene-related factors and/oramong associated protein-related factors, as well as factors that influence tumor growth in differentbiological models; (2) statistical design and evaluation strategies to assess the impact of experimentalinterventions in genes on relevant biological outcomes (cell apoptosis, tumor growth and development,therapeutic response); and (3) statistical decision making tools to make scientifically valid statementsrelated to key scientific hypotheses. The Biostatistics Core members will collaborate with projectinvestigators to interpret and synthesize study findings, and collaborate on the preparation of manuscripts.These collaborations will insure that the projects proposed will have high quality study designs andstatistical analysis plans that will provide a solid foundation for statistical models and inferences related tosignaling pathways in melanoma.
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