Core A. Administrative Core. This Core includes two parts: (1) an administrative component and (2) a component for biostatistics support of the Program. The administrative portion of this core is designed to provide fiscal management, to offer clerical and organizational support, to establish mechanisms for internal and external review of the Program (the latter via an external scientific advisory board), and to enhance the scientific interactions and collaborations among the Project and Core leaders. Fiscal management will include oversight of project and core budgets in accordance with policies and procedures of Yale University and the NIH, as well as oversight of staff appointments, salaries and fringe benefits, and other personnel issues. This core will also arrange meetings among Project and Core leaders, coordinate participation by Program faculty and staff in the Radiobiology Workshop and Journal Club series, and organize visits by the members of the board of externaladvisors. The adminsitrative core services are therefore essential for this Program to function as an effficient, cohesive unit. The biostatisticscomponent will provide all members of the Program with active consultation with qualified biostatisticians offering state-of-the-art methodology. These consultations will occur at all points of the research: from planning and design including sample size and power calculations to ongoing guidance during the data collection and support of manuscript writing for publication.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA129186-01
Application #
7318308
Study Section
Special Emphasis Panel (ZCA1-GRB-S (M1))
Project Start
2007-07-01
Project End
2012-06-30
Budget Start
2007-08-06
Budget End
2008-07-31
Support Year
1
Fiscal Year
2007
Total Cost
$82,235
Indirect Cost
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Penketh, Philip G; Shyam, Krishnamurthy; Baumann, Raymond P et al. (2016) When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments. Anal Biochem 508:34-7
Penketh, P G; Shyam, K; Baumann, R P et al. (2015) A simple and inexpensive method to control oxygen concentrations within physiological and neoplastic ranges. Anal Biochem 491:1-3
Penketh, Philip G; Shyam, Krishnamurthy; Zhu, Rui et al. (2014) Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W. Chem Res Toxicol 27:818-33
Lin, Z Ping; Ratner, Elena S; Whicker, Margaret E et al. (2014) Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors. Mol Cancer Res 12:381-393
Penketh, Philip G; Patridge, Eric; Shyam, Krishnamurthy et al. (2014) Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine. Chem Res Toxicol 27:1440-9
Lamb, Kristy L; Liu, Yanfeng; Ishiguro, Kimiko et al. (2014) Tumor-associated mutations in O? -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality. Mol Carcinog 53:201-10
Zhu, Rui; Baumann, Raymond P; Penketh, Philip G et al. (2013) Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine. J Med Chem 56:1355-9
Zhu, Rui; Baumann, Raymond P; Patridge, Eric et al. (2013) Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells. Bioorg Med Chem Lett 23:1853-9
Daley, James M; Niu, Hengyao; Sung, Patrick (2013) Roles of DNA helicases in the mediation and regulation of homologous recombination. Adv Exp Med Biol 767:185-202
Daley, James M; Sung, Patrick (2013) RIF1 in DNA break repair pathway choice. Mol Cell 49:840-1

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