Abstract

The proposed project aims to address a current gap in our understanding of the role of biological sex in overall survival among melanoma AJCC TNM stages IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID. We will evaluate methylome alterations and mutational burden in the primary tumors of 1000 melanoma patients with the goal of 1) identifying underlying mechanisms for observed disparities in melanoma overall survival between men and women, and 2) identifying subclasses of methylome alterations and mutational signatures associated with sex and survival.

Public Health Relevance

/PUBLIC HEALTH RELEVANCE The proposed project aims to address a current gap in our understanding of the role of biological sex in overall survival among melanoma AJCC TNM stages IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID. Data from the proposed project will provide insight into the link between sex, epigenetics and genetic mutational load, and melanoma survival, and will provide insight into important biomarkers for melanoma progression, and inform clinical decisions about the use of adjuvant immunotherapy. This important step towards increasing our understanding of the relationship between biological sex, methylation alterations, and tumor mutational burden, will be used to develop additional studies, setting the stage for additional breakthroughs in factors important for melanoma survival.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA206980-04S1
Application #
10063456
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Filipski, Kelly
Project Start
2017-06-01
Project End
2023-05-31
Budget Start
2020-07-01
Budget End
2021-05-31
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of New Mexico Health Sciences Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131

  Publications

Thomas, Nancy E; Edmiston, Sharon N; Orlow, Irene et al. (2018) Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes. J Invest Dermatol 138:2398-2404
Gorlov, Ivan; Orlow, Irene; Ringelberg, Carol et al. (2018) Identification of gene expression levels in primary melanoma associated with clinically meaningful characteristics. Melanoma Res 28:380-389
Miles, Jonathan A; Orlow, Irene; Kanetsky, Peter A et al. (2018) Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based GEM Study. J Invest Dermatol :
Gorlov, Ivan P; Pikielny, Claudio W; Frost, Hildreth R et al. (2018) Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples. BMC Bioinformatics 19:430
Thomas, Nancy E; Edmiston, Sharon N; Tsai, Yihsuan S et al. (2018) Utility of TERT Promoter Mutations for Cutaneous Primary Melanoma Diagnosis. Am J Dermatopathol :