Advanced imaging plays a vital role in neuro-oncology research. The goal of this Imaging Core, Core 4, is to provide expertise and access to advanced imaging equipment required by the various projects of this P01 proposal. The objective of the Core is to organize the needs of Projects 1-4 and match them with the requisite know-how and advanced technology. We will accomplish our objectives in three specific aims:
Specific Aim 1 : To utilize non-invasive imaging to diagnose GBM, evaluate longitudinal progression, and response to therapy.
Specific Aim 2 : To directly radiolabel our novel targeted therapeutics and evaluate long-term biodistribution and tumor targeting.
Specific Aim 3 : To image loco-regional therapy administration to ensure proper placement of our advanced delivery vehicles and proper therapeutic distribution. Thus, Core 4 will provide indispensable services to all Projects in this PPG application. It will comply with one of the most important requirements in developing efficient drug delivery means by offering direct visualization of malignant lesions, access of drugs to these lesions and changes in their response to therapy. Core 4 integration with all the projects represents a considerable strength of our PPG application.
High grade malignant gliomas are the leading cause of primary brain cancer deaths, afflicting close to 20,000 patients annually in the United States alone. Core 4 will use advanced multimodality imaging to assist investigators in Projects 1-4 of this P01 application, which is developing new innovative, clinically relevant anti- tumor strategies using novel delivery vehicles and drugs. Our advanced imaging methods promise to effectively assist in significant improvement of therapy against malignant brain cancers.
| Goswami, Ishan; Perry, Justin B; Allen, Mitchell E et al. (2018) Influence of Pulsed Electric Fields and Mitochondria-Cytoskeleton Interactions on Cell Respiration. Biophys J 114:2951-2964 |
| Sweeney, Daniel C; Weaver, James C; Davalos, Rafael V (2018) Characterization of Cell Membrane Permeability In Vitro Part I: Transport Behavior Induced by Single-Pulse Electric Fields. Technol Cancer Res Treat 17:1533033818792491 |
