Both methamphetamine dependence and HIV disease can result in central nervous system (CNS) damage. The overall aim of this Program Project is to determine the influence of current and past methamphetamine dependence on the emergence of HIV-associated neurocognitive disorders. Background: As the incidence of HIV infections/new cases of AIDS attributable to homosexual/bisexual risk has declined, the proportion of cases related to drug abuse has risen. Methamphetamine use may contribute to HIV neurotoxicity both by facilitating transport of HIV into the CNS and by activating the same excitotoxic pathways that have been implicated in neural damage from HIV. Program Aims: 1) to define the influence of methamphetamine on expression of HIV neurobehavioral disorders; 2) to delineate the neurobiological bases of these disorders. Methods: This Program has five interacting Scientific Projects linked by a Core. Projects on Neuropsychology, MR Morphometry, and MR Spectroscopy explore the anatomic and functional effects of HIV and methamphetamine. Projects on Neuropathology and CSF Virology/Markers explore the mechanisms and pathways of neural damage. The general plan calls for recruiting 180 HIV+ and 120 HIV- methamphetamine dependent (METH+) persons and 180 HIV+ and 120 HIV- controls with a negative history of methamphetamine abuse and/or dependence (METH-). Subjects will be examined in a longitudinal study with annual multidisciplinary evaluations (medical, neurobehavioral). Subsets of participants will receive MR morphometric, MR spectroscopic, and neuropathologic studies. Significance: Both methamphetamine and HIV infection can damage the brain; the joint effects of these factors require exploration. Our studies on anatomic and functional brain changes in vivo linked to neuropathologic studies can address molecular mechanisms and selective neuronal vulnerability. The CSF studies will determine if CSF is an appropriate window into CNS events. Linking this Program to the NIMH funded HIV Neurobehavioral Research Center (HNRC) allows us to take advantage of the critical mass of investigators and staff with expertise in longitudinal neurobehavioral research on HIV, and capitalizes on availability of resources for evaluating and tracking participants, and for data management and statistics, thereby maximizing the economy of this study of methamphetamine dependent individuals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
3P01DA012065-02S1
Application #
6344058
Study Section
Special Emphasis Panel (ZDA1 (19))
Program Officer
Nemeth-Coslett, Rosemarie V
Project Start
1999-07-01
Project End
2003-06-30
Budget Start
2000-09-01
Budget End
2001-06-30
Support Year
2
Fiscal Year
2000
Total Cost
$21,200
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Marquine, María J; Flores, Ilse; Kamat, Rujvi et al. (2018) A composite of multisystem injury and neurocognitive impairment in HIV infection: association with everyday functioning. J Neurovirol 24:549-556
Dufour, Catherine A; Marquine, María J; Fazeli, Pariya L et al. (2018) A Longitudinal Analysis of the Impact of Physical Activity on Neurocognitive Functioning Among HIV-Infected Adults. AIDS Behav 22:1562-1572
Oppenheim, Hannah; Paolillo, Emily W; Moore, Raeanne C et al. (2018) Neurocognitive functioning predicts frailty index in HIV. Neurology 91:e162-e170
Paolillo, Emily W; Gongvatana, Assawin; Umlauf, Anya et al. (2017) At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS. Alcohol Clin Exp Res 41:1518-1525
Marquine, María J; Montoya, Jessica L; Umlauf, Anya et al. (2016) The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study. Clin Infect Dis 63:694-702
Soontornniyomkij, Virawudh; Kesby, James P; Morgan, Erin E et al. (2016) Effects of HIV and Methamphetamine on Brain and Behavior: Evidence from Human Studies and Animal Models. J Neuroimmune Pharmacol 11:495-510
Bharti, Ajay R; McCutchan, Allen; Deutsch, Reena et al. (2016) Latent Toxoplasma Infection and Higher Toxoplasma gondii Immunoglobulin G Levels Are Associated With Worse Neurocognitive Functioning in HIV-Infected Adults. Clin Infect Dis 63:1655-1660
Bharti, Ajay R; Woods, Steven Paul; Ellis, Ronald J et al. (2016) Fibroblast growth factors 1 and 2 in cerebrospinal fluid are associated with HIV disease, methamphetamine use, and neurocognitive functioning. HIV AIDS (Auckl) 8:93-9
Marquine, M J; Sakamoto, M; Dufour, C et al. (2016) The impact of ethnicity/race on the association between the Veterans Aging Cohort Study (VACS) Index and neurocognitive function among HIV-infected persons. J Neurovirol 22:442-54
Ma, Qing; Vaida, Florin; Wong, Jenna et al. (2016) Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients. J Neurovirol 22:170-8

Showing the most recent 10 out of 132 publications