The Technology Core will provide outstanding critical analytical support for all three projects of the currentcompetitive renewal. By having a centralized resource to analyze the biogenic amines, metabolites,synthesizing enzymes, drug levels and their metabolites for this program, we will be able to substantiallyenhance efficiency, lower costs, and improve reliability across the projects. We employed a similarcentralized approach with the previous grant and found that centralization of these technical services wasextremely helpful and consequently we propose to maintain this strategy for the current proposal. This willbe achieved through the Technology Core which will be associated with the Center for Human Toxicology(CHT) at the University of Utah under the direction of Dennis Crouch, a co-director for the CHT and directorof the Technology Resource for most of the previous years 1-5 of this Program Project. The CHT is anonprofit laboratory administratively located at the University of Utah College of Pharmacy. The CHT'smission objectives are methods development and analytical services in support of clinical and basic researchin drug abuse and forensic toxicology. CHT is internationally recognized for its analytical capacity andfrequently contracts with NIDA, other federal and private agencies as well as foundations and insurancecompanies for analytical services. Because of its unparalleled experience and state-of-the-art resources, theCHT is considered by many one of the leading analytical drug laboratories in the world. This outstandingresource will greatly strengthen this Program Project and assure highly accurate and efficient analyticalservices for all of the projects.
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