Abstract

The overall goal of the project is to provide an accurate and comprehensive computer model of the entire auditory periphery that will simulate the cochlear-partition macromechanical and micromechanical vibrations, the hair-cell voltages, and the auditory-nerve-fiber discharge patterns produced by any acoustic signal presented anywhere in space. This model will be built around a currently working model of cochlear- partition vibrations (hydrodynamics) that was developed during the last grant period. The project has 3 specific aims.
The first aim i s to improve the accuracy of the current hydrodynamic model. Of particular importance is the low-frequency section of the model, which appears to require fundamentally different simulation than does the high-frequency section.
The second aim i s to expand the model by including representations of other parts in the peripheral transduction process: the middle and external ears, the hair-cell transduction processes, the hair- cell/afferent-nerve-fiber synapses, and the efferent systems.
The third aim i s to adapt the model, now representing the cat's periphery, to represent that of the human and the mustached bat.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
5P01DC000116-22
Application #
6238094
Study Section
Project Start
1997-03-01
Project End
1998-02-28
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
22
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Ruhland, Janet L; Yin, Tom C T; Tollin, Daniel J (2013) Gaze shifts to auditory and visual stimuli in cats. J Assoc Res Otolaryngol 14:731-55
Karino, Shotaro; Smith, Philip H; Yin, Tom C T et al. (2011) Axonal branching patterns as sources of delay in the mammalian auditory brainstem: a re-examination. J Neurosci 31:3016-31
Rhode, William S; Roth, G Linn; Recio-Spinoso, Alberto (2010) Response properties of cochlear nucleus neurons in monkeys. Hear Res 259:1-15
Moore, Jordan M; Tollin, Daniel J; Yin, Tom C T (2008) Can measures of sound localization acuity be related to the precision of absolute location estimates? Hear Res 238:94-109
Rhode, W S (2008) Response patterns to sound associated with labeled globular/bushy cells in cat. Neuroscience 154:87-98
Reale, R A; Calvert, G A; Thesen, T et al. (2007) Auditory-visual processing represented in the human superior temporal gyrus. Neuroscience 145:162-84
Tollin, Daniel J; Yin, Tom C T (2005) Interaural phase and level difference sensitivity in low-frequency neurons in the lateral superior olive. J Neurosci 25:10648-57
Zahorik, Pavel (2002) Direct-to-reverberant energy ratio sensitivity. J Acoust Soc Am 112:2110-7
Zahorik, Pavel (2002) Assessing auditory distance perception using virtual acoustics. J Acoust Soc Am 111:1832-46
Langendijk, E H; Kistler, D J; Wightman, F L (2001) Sound localization in the presence of one or two distracters. J Acoust Soc Am 109:2123-34

Showing the most recent 10 out of 18 publications