Abstract

This proposal describes five projects which focus on the anatomy, physiology and neurochemistry of the medial, lateral and sympathetic efferent innervation of the cochlea in developing and adult animals. Development is an additional common element in three of the five projects which focus on cell number regulation in the efferent system, pathfinding mechanisms of efferent axons, synaptogenesis and postsynaptic receptor maturation, and functional consolidation of efferent connections. The first project will continue to investigate the detailed anatomy of different subcomponents of the olivocochlear system. The second project will quantify numerical matching of efferent cells to their targets in control and mutant mice with different degrees of reduction in the periphery. The third project will continue to assess the physiological development of efferent function, focusing on the effect of early chronic differentiation. The fourth project will focus on the neurogenic regulation of cochlear blood flow using a new in vitro preparation of the spiral modiolar artery and will determine the functional interactions between the sympathetic efferent innervation and its target. The fifth project will continue to study the neurochemistry of the efferent system, focusing on cholinergic receptor subunits in adult and developing rats.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
5P01DC000215-18
Application #
6497847
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Luethke, Lynn E
Project Start
1992-04-01
Project End
2004-01-31
Budget Start
2002-02-01
Budget End
2004-01-31
Support Year
18
Fiscal Year
2002
Total Cost
$910,595
Indirect Cost

  Institution

Name
Father Flanagan's Boys' Home
Department
Type
DUNS #
City
Boys Town
State
NE
Country
United States
Zip Code
68010

  Publications

Yang, Tian; Jia, Zhonglin; Bryant-Pike, Whitney et al. (2014) Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations. Mol Genet Genomic Med 2:138-51
Fritzsch, Bernd; Tessarollo, Lino; Coppola, Enzo et al. (2004) Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance. Prog Brain Res 146:265-78
Cohn, Edward; Bhattacharya, Gautam; Pearsall, Nicole et al. (2004) Immunohistochemistry and reverse transcriptase-polymerase chain reaction as methods for diagnostic determination of usher syndrome type IIa. Laryngoscope 114:1310-4
Maklad, Adel; Fritzsch, Bernd (2003) Development of vestibular afferent projections into the hindbrain and their central targets. Brain Res Bull 60:497-510
Fritzsch, Bernd (2003) Development of inner ear afferent connections: forming primary neurons and connecting them to the developing sensory epithelia. Brain Res Bull 60:423-33
Maklad, Adel; Fritzsch, Bernd (2003) Partial segregation of posterior crista and saccular fibers to the nodulus and uvula of the cerebellum in mice, and its development. Brain Res Dev Brain Res 140:223-36
Xiang, Mengqing; Maklad, Adel; Pirvola, Ulla et al. (2003) Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation. BMC Neurosci 4:2
Maklad, Adel; Fritzsch, Bernd (2002) The developmental segregation of posterior crista and saccular vestibular fibers in mice: a carbocyanine tracer study using confocal microscopy. Brain Res Dev Brain Res 135:1-17
Fritzsch, B; Beisel, K W; Jones, K et al. (2002) Development and evolution of inner ear sensory epithelia and their innervation. J Neurobiol 53:143-56
Judice, Tiffany N; Nelson, Nathan C; Beisel, Chase L et al. (2002) Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients. Brain Res Brain Res Protoc 9:65-76

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