Anatomically determined nasal airflow patterns are involved in a number of physiological mechanisms, not the least of which is olfaction. Obviously if the nasal anatomy is such that odorant molecules cannot reach the olfactory region, odorant perception is unlikely. Further, the extent to which the airflow towards the olfactory region is reduced may be reflected in the extent to which olfaction is compromised. Therefore, one of the long range goals of this study is to describe the relationship between nasal anatomy and nasal airflow patterns. This relationship will first be studied in using a radiographic technique that quantifies the airflow patterns through an anatomically correct model of the human nasal passageways. After the normal airflow patterns have been determined, the model will be changed to simulate conditions like nasal spurs, polyps, tumors, and traumatic deformities. The airflow patterns will again be determined, and the extent to which the airflow patterns have changed will be observed. This study will attempt to determine the degree to which the hyposmia that often accompanies the above conditions may be explained by changes in the nasal airflow patterns. Another long term goal of this project is to modify the techniques used in the model in order to visualize the airflow patterns in humans.

Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Upstate Medical University
Department
Type
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210
Youngentob, Steven L; Schwob, James E (2006) Odorant identification and quality perception following methyl bromide-induced lesions of the olfactory epithelium. Behav Neurosci 120:1346-55
Holbrook, Eric H; Leopold, Donald A; Schwob, James E (2005) Abnormalities of axon growth in human olfactory mucosa. Laryngoscope 115:2144-54
White, Theresa L; Kurtz, Daniel B (2003) The relationship between metacognitive awareness of olfactory ability and age in people reporting chemosensory disturbances. Am J Psychol 116:99-110
Schwob, J E; Saha, S; Youngentob, S L et al. (2001) Intranasal inoculation with the olfactory bulb line variant of mouse hepatitis virus causes extensive destruction of the olfactory bulb and accelerated turnover of neurons in the olfactory epithelium of mice. Chem Senses 26:937-52
Youngentob, S L; Schwob, J E; Saha, S et al. (2001) Functional consequences following infection of the olfactory system by intranasal infusion of the olfactory bulb line variant (OBLV) of mouse hepatitis strain JHM. Chem Senses 26:953-63
Hornung, D E; Smith, D J; Kurtz, D B et al. (2001) Effect of nasal dilators on nasal structures, sniffing strategies, and olfactory ability. Rhinology 39:84-7
Kurtz, D B; Sheehe, P R; Kent, P F et al. (2000) Odorant quality perception: a metric individual differences approach. Percept Psychophys 62:1121-9
Kurtz, D B; White, T L; Hayes, M (2000) The labeled dissimilarity scale: a metric of perceptual dissimilarity. Percept Psychophys 62:152-61
Schwob, J E; Youngentob, S L; Ring, G et al. (1999) Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: timing and extent of reinnervation. J Comp Neurol 412:439-57
Kurtz, D B; White, T L; Hornung, D E et al. (1999) What a tangled web we weave: discriminating between malingering and anosmia. Chem Senses 24:697-700

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