This project is concerned with hearing loss associated with aging and with exposure to low levels of noise. Five projects are planned. Project #1 proposes to develop an animal model of presbyacusis and to study hypothesized interactions between aging effects and exposure to noise. Project #2 is a clinical study of human presbyacusis and control subjects with the major purpose being to categorize or develop profiles of presbyacusis that are based on current audiological-otological-medical information. Project #3 addresses the pathophysiology of presbyacusis by examining the physiology of the endolymphatic duct, and the neurophysiology of the auditory nerve and brainstem. Project #4 focuses on the histopathology of the cochlea, particularly the sensory and supporting cells, stria vascularis, and spiral ligament, including vasculature. Project #5 is a histochemical study of the cochlea which extends Project #4 by providing precise information about the presence and distribution of specific molecular constituents in the cochlea. Experimental animals are Mongolian gerbils who are born are born and reared in a quiet, acoustically controlled environment. Project #1 provides experimental animals for Projects 3, 4, and 5. Thus, a given animal is studied with respect to cochlear physiology, neurophysiology of the auditory nerve and brainstem, and cochlear histopathology and histochemistry. These extensive animal data in combination with clinical and experimental data from the humans of Project #2 provide a comprehensive program of research on presbyacusis and hearing loss in general.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
2P01DC000422-06
Application #
3094868
Study Section
Special Emphasis Panel (SRC (04))
Project Start
1987-07-01
Project End
1997-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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Hao, Xinping; Xing, Yazhi; Moore, Michael W et al. (2014) Sox10 expressing cells in the lateral wall of the aged mouse and human cochlea. PLoS One 9:e97389
Luo, Hongmei; Yount, Caroline; Lang, Hainan et al. (2013) Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence. Lung Cancer 81:167-73
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Shunmugavel, Anandakumar; Khan, Mushfiquddin; Chou, Peter C-te et al. (2012) Spinal cord injury induced arrest in estrous cycle of rats is ameliorated by S-nitrosoglutathione: novel therapeutic agent to treat amenorrhea. J Sex Med 9:148-58
Yan, Denise; Xing, Yazhi; Ouyang, Xiaomei et al. (2012) Analysis of miR-376 RNA cluster members in the mouse inner ear. Int J Exp Pathol 93:450-7
Xing, Yazhi; Samuvel, Devadoss J; Stevens, Shawn M et al. (2012) Age-related changes of myelin basic protein in mouse and human auditory nerve. PLoS One 7:e34500
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Kilpatrick, Lauren A; Zhu, Juhong; Lee, Fu-Shing et al. (2011) Role of stromal cell-derived factor-1 expression in the injured mouse auditory nerve. Otolaryngol Head Neck Surg 145:1007-15
Kilpatrick, L A; Li, Q; Yang, J et al. (2011) Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear. Gene Ther 18:569-78

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