Abstract

The central theme of this subproject is the assessment of aspects of vestibular performance that are functionally significant to normal subjects and patients. Traditional tests are not conducted under natural conditions and thus may not be reflective of the systems true mechanisms. This subproject has four specific aims. First the angular and linear vestibulo-ocular reflexes and visual vestibular interaction will be quantified during walking, standing, and running conditions in normal subjects and patients with vestibular syndromes. Second, eccentric rotation tests of otolithic function will be developed that combine linear acceleration with angular rotations in pitch and yaw. Third, the VOR initiation in both yaw and pitch will be evaluate as a functional vestibular test. Fourth, tests of dynamic visual acuity will be developed as an index of vestibular performance during gaze stabilization. Magnetic search coil and flux gate sensors will be used to make precise measurements of eye and head movements. Effects of aging, peripheral vestibular loss and cerebellar dysfunction will be assessed on these reflexes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
5P01DC002952-05
Application #
6410269
Study Section
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
2001
Total Cost
$353,426
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Dranias, Mark R; Grossberg, Stephen; Bullock, Daniel (2008) Dopaminergic and non-dopaminergic value systems in conditioning and outcome-specific revaluation. Brain Res 1238:239-87
Grossberg, Stephen; Bullock, Daniel; Dranias, Mark R (2008) Neural dynamics underlying impaired autonomic and conditioned responses following amygdala and orbitofrontal lesions. Behav Neurosci 122:1100-25
Shook, Steven J; Mamsa, Hafsa; Jen, Joanna C et al. (2008) Novel mutation in KCNA1 causes episodic ataxia with paroxysmal dyspnea. Muscle Nerve 37:399-402
Tian, Jun-Ru; Ishiyama, Akira; Demer, Joseph L (2007) Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translation. Exp Brain Res 176:575-87
Richards, Anna; van den Maagdenberg, Arn M J M; Jen, Joanna C et al. (2007) C-terminal truncations in human 3'-5'DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nat Genet 39:1068-70
Jen, J C; Lee, H; Cha, Y H et al. (2006) Genetic heterogeneity of autosomal dominant nonprogressive congenital ataxia. Neurology 67:1704-6
Tian, Jun-Ru; Crane, Benjamin T; Demer, Joseph L (2005) Human surge linear vestibulo-ocular reflex during tertiary gaze viewing. Ann N Y Acad Sci 1039:489-93
Paine, R W; Grossberg, S; Van Gemmert, A W A (2004) A quantitative evaluation of the AVITEWRITE model of handwriting learning. Hum Mov Sci 23:837-60
Lopez, Ivan; Ayala, Carlos; Honrubia, Vicente (2003) Synaptophysin immunohistochemistry during vestibular hair cell recovery after gentamicin treatment. Audiol Neurootol 8:80-90
Crane, Benjamin T; Tian, Junru; Wiest, Gerald et al. (2003) Initiation of the human heave linear vestibulo-ocular reflex. Exp Brain Res 148:247-55

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