Abstract

The relative abilities of selected oral bacterial species to attach to teeth and to oral mucosal surfaces will be studied using both in vitro and in vivo approaches. The influence of salivary and seorus components on bacterial attachment will be determined. Components studied will include those likely present in the acquired pellicle covering teeth as well as those free in oral fluids; special emphasis will be placed upon blood-group reactive mucins. Possible relationships between the composition of oral fluids as it influences bacterial attachment and susceptibility to infection will be determined. The influence of antibodies present in oral secretions on the adherence, colonization, antigenic composition and virulence of oral organisms will be assessed. The influence of various lectins, including those contained in certain foods, on the adherence and colonization of selected oral bacteria will be assessed. The roles of pili in colonization of Bacteroides relaninogenicus, and of motility for the colonization of Selenomonas sputigena and Campylobacter species will be evaluated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE002847-17
Application #
4692762
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Forsyth Institute
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code

  Publications

Niederman, R; Naleway, C; Lu, B Y et al. (1995) Subgingival temperature as a gingival inflammatory indicator. J Clin Periodontol 22:804-9
Duncan, M J; Nakao, S; Skobe, Z et al. (1993) Interactions of Porphyromonas gingivalis with epithelial cells. Infect Immun 61:2260-5
Haffajee, A D; Socransky, S S; Goodson, J M (1992) Subgingival temperature (I). Relation to baseline clinical parameters. J Clin Periodontol 19:401-8
Socransky, S S; Haffajee, A D (1992) The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol 63:322-31
Haffajee, A D; Socransky, S S; Goodson, J M (1992) Subgingival temperature (II). Relation to future periodontal attachment loss. J Clin Periodontol 19:409-16
Haffajee, A D; Socransky, S S; Smith, C et al. (1992) The use of DNA probes to examine the distribution of subgingival species in subjects with different levels of periodontal destruction. J Clin Periodontol 19:84-91
Haffajee, A D; Socransky, S S (1992) Effect of sampling strategy on the false-negative rate for detection of selected subgingival species. Oral Microbiol Immunol 7:57-9
Haffajee, A D; Socransky, S S; Smith, C et al. (1992) Subgingival temperature (III). Relation to microbial counts. J Clin Periodontol 19:417-22
Socransky, S S; Haffajee, A D (1991) Microbial mechanisms in the pathogenesis of destructive periodontal diseases: a critical assessment. J Periodontal Res 26:195-212
Gibbons, R J; Hay, D I; Schlesinger, D H (1991) Delineation of a segment of adsorbed salivary acidic proline-rich proteins which promotes adhesion of Streptococcus gordonii to apatitic surfaces. Infect Immun 59:2948-54

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