Abstract

The aim of the proposed research is to assess the peripheral and central sequelae of trigeminal (V) nerve damage and to define mechanisms underlying injury-induced V reorganization. Anatomical, physiological, immunocytochemical, neurochemical, and computer-assisted morphometric techniques will be used to provide basic data relevant to chronic and acute oro-facial pain, acquired craniofacial anomalies and methods for reconstruction of congenital oro-facial malformations. Seven projects are proposed. Each examines multiple aspects of injury-induced V plasticity and/or normal development in rodents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE007734-09
Application #
2129886
Study Section
Special Emphasis Panel (SRC (08))
Project Start
1989-12-01
Project End
1994-11-30
Budget Start
1993-12-01
Budget End
1994-11-30
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Saint Louis University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103

  Publications

Jacquin, Mark F; Arends, Joop J A; Renehan, William E et al. (2015) Whisker-related circuitry in the trigeminal nucleus principalis: Topographic precision. Somatosens Mot Res 32:8-20
Xiang, Chuanxi; Arends, Joop J A; Jacquin, Mark F (2014) Whisker-related circuitry in the trigeminal nucleus principalis: ultrastructure. Somatosens Mot Res 31:141-51
Vadivelu, Sudhakar; Platik, Marina M; Choi, Luke et al. (2005) Multi-germ layer lineage central nervous system repair: nerve and vascular cell generation by embryonic stem cells transplanted in the injured brain. J Neurosurg 103:124-35
Pluto, Charles P; Chiaia, Nicolas L; Rhoades, Robert W et al. (2005) Reducing contralateral SI activity reveals hindlimb receptive fields in the SI forelimb-stump representation of neonatally amputated rats. J Neurophysiol 94:1727-32
Genc, Baris; Ulupinar, Emel; Erzurumlu, Reha S (2005) Differential Trk expression in explant and dissociated trigeminal ganglion cell cultures. J Neurobiol 64:145-56
Gandhi, Rohan; Ryals, Janelle M; Wright, Douglas E (2004) Neurotrophin-3 reverses chronic mechanical hyperalgesia induced by intramuscular acid injection. J Neurosci 24:9405-13
McDonald, John W; Becker, Daniel; Holekamp, Terrence F et al. (2004) Repair of the injured spinal cord and the potential of embryonic stem cell transplantation. J Neurotrauma 21:383-93
Genc, Baris; Ozdinler, P Hande; Mendoza, April E et al. (2004) A chemoattractant role for NT-3 in proprioceptive axon guidance. PLoS Biol 2:e403
Ulupinar, Emel; Unal, Nedim; Erzurumlu, Reha S (2004) Morphometric analysis of embryonic rat trigeminal neurons treated with different neurotrophins. Anat Rec A Discov Mol Cell Evol Biol 277:396-407
Wright, Douglas E; Ryals, Janelle M; McCarson, Kenneth E et al. (2004) Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons. J Peripher Nerv Syst 9:242-54

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