The Biostatistical Core will work with all investigators in the Geriatric Oral Science Center. Specifically, the Biostatistical Core will: 1. Collaborate with investigators on the statistical and scientific aspects of study design for each project. The issues to be addressed are definition of endpoints, determination of criteria for selection and enrollment, methods for registration and follow-up, reliability of risk factor assessment, identification of and methods of controlling for possible bias factors, methods for assuring data quality integrity, and adequate sample sizes. 2. Work with investigators on appropriate instruments for data collection. 3. Develop and operate a computer system for data collection, management and statistical analysis. To select and develop appropriate computer software for these functions. 4. Develop and implement a registration and tracking system for study participants. 5. Prepare and distribute monthly accrual reports and quarterly interim reports on data completeness and quality. To monitor study progress to detect problems in implementation or compliance with study protocols. 6. Develop a plan for statistical analysis and graphical presentation of the data in collaboration with project investigators. 7. Develop and/or apply new statistical methodology for the analysis of study results and to develop software to implement these methods. 8. Prepare the annual and final reports on each study and to collaborate with project investigators on the preparation of scientific papers describing study results.
| Rubenfire, Melvyn; Grossman, Natalie S; Kaciroti, Niko et al. (2007) Anaerobic dental flora and the acute coronary syndrome. Coron Artery Dis 18:111-6 |
| Terpenning, M S; Taylor, G W; Lopatin, D E et al. (2001) Aspiration pneumonia: dental and oral risk factors in an older veteran population. J Am Geriatr Soc 49:557-63 |
| Loesche, W J; Grossman, N S (2001) Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev 14:727-52, table of contents |
| Bretz, W A; Loesche, W J; Chen, Y M et al. (2000) Minor salivary gland secretion in the elderly. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:696-701 |
| Taylor, G W; Loesche, W J; Terpenning, M S (2000) Impact of oral diseases on systemic health in the elderly: diabetes mellitus and aspiration pneumonia. J Public Health Dent 60:313-20 |
| Loesche, W J (1999) The antimicrobial treatment of periodontal disease: changing the treatment paradigm. Crit Rev Oral Biol Med 10:245-75 |
| Loesche, W J; Taylor, G W; Dominguez, L D et al. (1999) Factors which are associated with dental decay in the older individual. Gerodontology 16:37-46 |
| Langmore, S E; Terpenning, M S; Schork, A et al. (1998) Predictors of aspiration pneumonia: how important is dysphagia? Dysphagia 13:69-81 |
| Loesche, W J; Lopatin, D E (1998) Interactions between periodontal disease, medical diseases and immunity in the older individual. Periodontol 2000 16:80-105 |
| Loesche, W J; Schork, A; Terpenning, M S et al. (1998) Assessing the relationship between dental disease and coronary heart disease in elderly U.S. veterans. J Am Dent Assoc 129:301-11 |
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