Abstract

Data management for the Program Project will be provided through the Biostatistical Core. Dr. Richard Raubertas (CV included), who has worked extensively with us in the past and is a member of our internal Advisory Committee, will supervise the statistical core. He will operate from the Department of Biostatistics, School of Medicine and Dentistry. This Department is well-staffed by faculty. computer programmers and research associates. In addition. the Department has 2 NIH supported post-doctoral training programs. The Department has up-to-date computer hardware and software; for example, it has a local Area Vax Cluster running VMS. The LAVC consists of three Vaxstation 4OOOs and three Vaxstation 3l00s with a total of 152 MB of memory and 14.7 GB of disk space on the machines. Statistical software on the Focal Area Vax Cluster includes Fortran, NAG, SAS, SASGRAPH, BMDP, GLIM, MINITAB and INGRES. Thus, it is clear that biostatistical support is readily available to the program project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE011549-02
Application #
5210271
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Bowen, W H; Koo, H (2011) Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms. Caries Res 45:69-86
Bowen, William H; Lawrence, Ruth A (2005) Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose. Pediatrics 116:921-6
Barboza-Silva, E; Castro, A C D; Marquis, R E (2005) Mechanisms of inhibition by fluoride of urease activities of cell suspensions and biofilms of Staphylococcus epidermidis, Streptococcus salivarius, Actinomyces naeslundii and of dental plaque. Oral Microbiol Immunol 20:323-32
Chatfield, Christa H; Koo, Hyun; Quivey Jr, Robert G (2005) The putative autolysin regulator LytR in Streptococcus mutans plays a role in cell division and is growth-phase regulated. Microbiology 151:625-31
Culp, D J; Quivey, R Q; Bowen, W H et al. (2005) A mouse caries model and evaluation of aqp5-/- knockout mice. Caries Res 39:448-54
Zhu, Qingyuan; Quivey, Robert G; Berger, Andrew J (2004) Measurement of bacterial concentration fractions in polymicrobial mixtures by Raman microspectroscopy. J Biomed Opt 9:1182-6
Fozo, Elizabeth M; Quivey Jr, Robert G (2004) The fabM gene product of Streptococcus mutans is responsible for the synthesis of monounsaturated fatty acids and is necessary for survival at low pH. J Bacteriol 186:4152-8
Fozo, Elizabeth M; Quivey Jr, Robert G (2004) Shifts in the membrane fatty acid profile of Streptococcus mutans enhance survival in acidic environments. Appl Environ Microbiol 70:929-36
Phan, T-N; Buckner, T; Sheng, J et al. (2004) Physiologic actions of zinc related to inhibition of acid and alkali production by oral streptococci in suspensions and biofilms. Oral Microbiol Immunol 19:31-8
Fozo, Elizabeth M; Kajfasz, Jessica K; Quivey Jr, Robert G (2004) Low pH-induced membrane fatty acid alterations in oral bacteria. FEMS Microbiol Lett 238:291-5

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